Christoph J Meinrenken

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Phasic transmitter release at synapses in the mammalian CNS is regulated by local [Ca2+] transients, which control the fusion of readily releasable vesicles docked at active zones (AZs) in the presynaptic membrane. The time course and amplitude of these [Ca2+] transients critically determine the time course and amplitude of the release and thus the(More)
During the last decade, advances in experimental techniques and quantitative modelling have resulted in the development of the calyx of Held as one of the best preparations in which to study synaptic transmission. Here we review some of these advances, including simultaneous recording of pre- and postsynaptic currents, measuring the Ca2+ sensitivity of(More)
LCA experts need to accept that although ISO standards and similar academic work are extremely important, practitioners have issued a clear call for more practical guidance. Resisting this movement instead of providing constructive and helpful insight would lead to the creation of subpar standards and inaccurate PCFs. Life cycle assessment (LCA) has come a(More)
iii Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of the National Institute of Standards and Technology (NIST). Additionally, neither NIST nor any of its employees make any warranty, expressed or implied, nor assume any legal liability or responsibility for the accuracy,(More)
PAS2050 and the forthcoming WRI and ISO14067 standards have helped to propel carbon footprinting from an LCA sub-discipline to the mainstream. However, applying these standards to portfolios of many products/services is immensely time consuming. Even if achieved, such footprinting often fails to inform company-wide carbon reduction strategies because(More)
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