Christoph Heinrich

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Isogeometric Analysis uses NURBS representations of the domain for performing numerical simulations. The first part of this paper presents a variational framework for generating NURBS parameteriza-tions of swept volumes. The class of these volumes covers a number of interesting free-form shapes, such as blades of turbines and propellers, ship hulls or wings(More)
Cell lines for industrial pharmaceutical protein production processes need to be robust, fast-growing, and high-producing. In order to find such cells, we performed a high passage cultivation of monoclonal antibody producing Chinese hamster ovary (CHO) cells in shaking flasks for more than 420 days. Examinations of cell growth, productivity, intracellular(More)
Introduction For industrial pharmaceutical protein production fast growing, high producing and robust cell lines are required. To select pH-shift permissive and faster growing sub-populations, the CHO DP-12 cell line was serially subcultured for more than four hundred days in shaker flasks. Initial adaptation to growth in suspension was carried out in(More)
Background State-of-the-art medium and feed development has proven its potential for increasing bioprocess efficiency many times. By the application of such advanced chemically defined and animal component-free formulations, in combination with recent cell lines, the yield of mamma-lian cell cultures was pushed to the binary gram per liter level. In this(More)