Christoph Heinrich

Learn More
Isogeometric Analysis uses NURBS representations of the domain for performing numerical simulations. The first part of this paper presents a variational framework for generating NURBS parameteriza-tions of swept volumes. The class of these volumes covers a number of interesting free-form shapes, such as blades of turbines and propellers, ship hulls or wings(More)
Background For industrial pharmaceutical protein production fast growing, high producing and robust cell lines are required. To select more pH shift permissive and fast growing sub-populations, the CHO DP-12 (ATCC clone #1934) cell line, an anti-IL8 antibody producing CHO K1 (DHFR) clone, was continuously subcultured at high viability (>90 %) for more than(More)
Introduction In recent years measurement of permittivity signal has been increasingly used for online biomass monitoring of cell cultures. Breweries use it as an established method for fermenter inoculation and bioprocess control for instance [1]. In the case of animal cell cultures the correlation between permittivity and viable cell densities determined(More)
Introduction For industrial pharmaceutical protein production fast growing, high producing and robust cell lines are required. To select pH-shift permissive and faster growing sub-populations, the CHO DP-12 cell line was serially subcultured for more than four hundred days in shaker flasks. Initial adaptation to growth in suspension was carried out in(More)
Background State-of-the-art medium and feed development has proven its potential for increasing bioprocess efficiency many times. By the application of such advanced chemically defined and animal component-free formulations, in combination with recent cell lines, the yield of mamma-lian cell cultures was pushed to the binary gram per liter level. In this(More)