Christoph Biesemann

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Cryptochromes are blue-light receptors that have presumably evolved from the DNA photolyase protein family, and the genomes of many organisms contain genes for both types of molecules. Both protein structures resemble each other, which suggests that light control and light protection share a common ancient origin. In the genome of the filamentous fungus(More)
For decades, neuroscientists have used enriched preparations of synaptic particles called synaptosomes to study synapse function. However, the interpretation of corresponding data is problematic as synaptosome preparations contain multiple types of synapses and non-synaptic neuronal and glial contaminants. We established a novel Fluorescence Activated(More)
Etienne Herzog,1,2,3,4* Fabien Nadrigny,5,6,7* Katlin Silm,2,3,4* Christoph Biesemann,1 Imke Helling,9 Tiphaine Bersot,2,3,4 Heinz Steffens,5,11,12 Richard Schwartzmann,8 U. Valentin Nägerl,6,7,9 Salah El Mestikawy,2,3,4 JeongSeop Rhee,1 Frank Kirchhoff,5,10 and Nils Brose1 1Department of Molecular Neurobiology, Max Planck Institute of Experimental(More)
Synaptic vesicles (SVs) from excitatory synapses carry vesicular glutamate transporters (VGLUTs) that fill the vesicles with neurotransmitter. Although the essential function of VGLUTs as glutamate transporters has been well established, the evidence for additional cell-biological functions is more controversial. Both VGLUT1 and VGLUT2 disruptions in mice(More)
The vesicular glutamate transporter VGLUT1 loads synaptic vesicles with the neurotransmitter glutamate and thereby determines glutamate release at many synapses in the mammalian brain. Due to its function and selective localization, VGLUT1 is one of the most specific markers for glutamatergic synaptic vesicles. It has been used widely to identify(More)
For several decades, neurobiologists have used subcellular fractionation methods to analyze the molecular structure and some functional features of the cells in the central nervous system. Indeed, brain tissue contains a complex intermingled network of neuronal, glial, and vascular cells. To reduce this complexity biochemists have optimized fractionation(More)
Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus. Media with simple sugars are more favorable for aflatoxin biosynthesis, media containing 0.1 M, or higher, of a suitable carbohydrate source will support biosynthesis of aflatoxin. This research is aimed at identifying genes(More)
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