Christoph Altmann

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1 We have compared the signalling mechanisms involved in the pertussis toxin-sensitive and -insensitive contraction of rat isolated mesenteric microvessels elicited by sphingosylphosphorylcholine (SPC) and noradrenaline (NA), respectively. 2 The phospholipase D inhibitor butan-1-ol (0.3%), the store-operated Ca(2+) channel inhibitor SK>F 96,365 (10 microM),(More)
The direct determinants of coronary flow are lumen area and blood flow velocity; however, the precise mechanisms that control these factors are not fully understood. The aim of the present study was to assess by which mechanisms lumen area and coronary flow velocity interact with hemodynamic and morphometric factors, thereby influencing coronary flow.(More)
1 The lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, have been reported to activate platelets. Here we examined effects of the naturally occurring related sphingosylphosphorylcholine (SPC) on human platelet function. 2 Platelet activation was determined as aggregation, elevation of intracellular Ca(2+) concentrations, surface(More)
Runge Kutta Discontinuous Galerkin (RKDG) schemes can provide highly accurate solutions for a large class of important scientific problems. Using them for problems with shocks and other discontinuities requires that one has a strategy for detecting the presence of these discontinuities. Strategies that are based on total variation diminishing (TVD) limiters(More)
Die transmyokardiale Laserrevaskularisierung ist ein modernes Therapiekonzept bei Patienten mit schwerer koronarer Herzerkrankung, die weder einem katheterinterventionellen noch einem bypasschirurgischen Vorgehen oder einer Herztransplantation zugänglich sind. Die initiale Idee, durch transmyokardiale Kannäle eine Verbesserung der Myokardperfusion zu(More)
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