Christof Karmonik

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Using data obtained from 3D digital subtraction angiography acquisitions, computational fluid dynamics techniques were used first to assess hemodynamic factors in geometrically correct models of 3 paraclinoid aneurysms and then again for assessment after virtual removal of the aneurysms and reconstruction of the parent artery. Simulations revealed an area(More)
Background Coarctation of the aorta (CoA), a narrowing of the aorta, accounts for approximately 10% of congenital heart defects in the western world. Due to the reduction in diameter, high pressure gradients can appear across the aortic coarctation, resulting in an increased cardiac workload. Current therapies, either surgical or minimally-invasive, aim to(More)
Blood-oxygenation-level-dependent (BOLD) contrast in magnetic resonance (MR) imaging of skeletal muscle mainly depends on changes of oxygen saturation in the microcirculation. In recent years, an increasing number of studies have evaluated the clinical relevance of skeletal muscle BOLD MR imaging in vascular diseases, such as peripheral arterial occlusive(More)
PURPOSE To demonstrate the capability of computational fluid dynamics (CFD) for quantifying hemodynamic forces pretreatment/posttreatment in type B aortic dissection (TB-AD). METHODS From CFD simulations initialized with dynamic magnetic resonance image data, wall shear stress (WSS) and dynamic pressure (dynP) changes post endovascular treatment were(More)
BACKGROUND Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a central role in arterial wall remodeling, affecting stability of fibrous caps covering atherosclerotic plaques. The objective of this study was to determine the spatial distribution of TIMP mass and MMP mass and activity of carotid endarterectomy (CEA) tissues and relate it to(More)
PURPOSE Computational fluid dynamics (CFD) simulations are increasingly used to model cerebral aneurysm hemodynamics. We investigated the capability of phase contrast magnetic resonance imaging (pcMRI), guided by specialized software for optimal slice definition (NOVA, Vassol Inc.) as a non-invasive method to measure intra-aneurysmal blood flow patterns(More)
This study demonstrates the feasibility of detecting motor intent from brain activity of chronic stroke patients using an asynchronous electroencephalography (EEG)-based brain machine interface (BMI). Intent was inferred from movement related cortical potentials (MRCPs) measured over an optimized set of EEG electrodes. Successful intent detection triggered(More)
OBJECT Unruptured posterior communicating artery (PCoA) aneurysms with oculomotor nerve palsy (ONP) have a very high risk of rupture. This study investigated the hemodynamic and morphological characteristics of intracranial aneurysms with high rupture risk by analyzing PCoA aneurysms with ONP. METHODS Fourteen unruptured PCoA aneurysms with ONP, 33 ruptured(More)
Outcome prediction in DeBakey Type III aortic dissections (AD) remains challenging. Large variations in AD morphology, physiology and treatment exist. A patient-specific approach towards a detailed understanding of the distinct features of each single case might be needed to account for this variation. In particular, an improved characterization of(More)
PURPOSE Flow diverters (FD) are increasingly being considered for treating large or giant wide-neck aneurysms. Clinical outcome is highly variable and depends on the type of aneurysm, the flow diverting device and treatment strategies. The objective of this study was to analyze the effect of different flow diverting strategies together with parent artery(More)