Christo Marais

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BACKGROUND Dabigatran is an oral anticoagulant direct thrombin inhibitor recently registered in South Africa (SA) to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation (AF). Owing to the price disparity between warfarin (the current gold standard for treatment of patients with AF) and dabigatran, we conducted an economic(More)
Varicella-zoster virus causes chickenpox (CP) and after reactivation herpes zoster (HZ). Vaccines are available against both diseases warranting an assessment of the pre-vaccination burden of disease. We collected data from relevant Belgian databases and performed five surveys of CP and HZ patients. The rates at which a general practitioner is visited at(More)
OBJECTIVES To identify key determinants explaining country-year variations in antibiotic use and resistance. METHODS Ambulatory antibiotic use data [in defined daily doses per 1000 inhabitants per day (DIDs)] for 19 European countries from 1999 to 2007 were collected, along with 181 variables describing countries in terms of their agriculture, culture,(More)
La radiofréquence de l’œsophage (RFO) est un traitement endoscopique disponible dans la palette des méthodes de traitement endoscopique de l’œsophage de Barrett (OB). Son efficacité et faible morbidité de gravité modérée ont été démontrées dans des études prospectives et/ou randomisées. Décrire l’utilisation de la RFO au quotidien, ses résultats et les(More)
Commonly cited requirements for bridging the " science-practice divide " between practitioners and scientists include: political support, communication and experimentation. The Subtropical Thicket Restoration Programme was established in 2004 to catalyse investment in large-scale restoration of degraded subtropical thicket in the Eastern Cape, 4329 South(More)
Okadaic acid (OA), the main toxin responsible for diarrheic shellfish poisoning (DSP) has toxicity for Daphnia magna (EC50 = 15 +/- 1.8 micrograms/l). A Daphnia bioassay was developed and used to analyse okadaic acid in mussel extracts. A linear correlation was found between OA concentration determined by the Daphnia bioassay and by HPLC assay (r = 0.85; p(More)
  • C Marais
  • 1978
A univocal disorder of dopaminergic activity in the nerve structures responsible for extra-pyramidal motility does not take into account the total phenomena seen in psychomotor neurological studies. The hypothesis of two categories of dopaminergic receptors-respectively excitatory (DA) and inhibitory (DAi)--in the striatal and mesolimbic structures(More)
Oestradiol-17beta and progesterone were assayed in the plasma of 32 nymphomaniac cows. In 21 cases oestradiol-17beta concentrations were higher than those recorded during the preovulatory surge of normal cyclic cows. However, for a further 5 nymphomaniac cows oestradiol-17beta concentrations were within the range of those recorded in normal cows during the(More)
  • C A Marais
  • 1981
In a multicentre trial a single daily oral dose of indapamide 2.5 mg (Natrilix; Servier) was prescribed to 387 hypertensive patients by their general practitioners for a period of 12 weeks, the common protocol permitting adjuvant therapy where necessary. Excellent control was achieved in indapamide alone and in 51.2% of 123 patients with more severe(More)