Christine Wei Wu

Learn More
In most tissues, the prevailing view is that stem cell (SC) niches are generated by signals from within the nearby tissue environment. Here, we define genetic changes altered in hair follicle (HF) SCs in mice treated with a potent SC activator, cyclosporine A (CSA), which inhibits the phosphatase calcineurin (CN) and the activity of the transcription factor(More)
We discuss the problem of using constraint models to force generated graphs to be connected. We represent the graph as a simple adjacency matrix, and then attempt to post constraints ensuring connectiv-ity. Doing this using standard modelling primitives is harder than expected, because of a problem with our use of the implication operator. We develop a(More)
Many real-world scheduling problems are subject to change, and scheduling solutions should be robust to those changes. We consider a single-machine scheduling problem where the processing time of each activity is characterized by a normally-distributed random variable, and we attempt to minimize flowtime. We develop an initial constraint model for(More)
Immunosuppressive therapies using calcineurin inhibitors, such as cyclosporine A, are associated with a higher incidence of squamous cell carcinoma formation in mice and humans. Calcineurin is believed to suppress tumorigenesis in part through Nfatc1, a transcription factor expressed primarily in hair follicle bulge stem cells in mice. However, mice(More)
  • 1