Christine Saraceni

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Acute perturbations in the hemostatic balance of anticoagulation and procoagulation antecede the manifestation of purpura fulminans, a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin. Hallmarks include small vessel thrombosis, tissue necrosis and disseminated intravascular thrombosis. The course may be rapidly fulminant(More)
Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma. The prognosis of PBL patients is poor. The majority of patients succumb to a fulminant disease course, with most dying in the first year after diagnosis. The small number of HIV-negative PBL cases reported in the literature to date is composed of single case(More)
1116 Journal of Thoracic Oncology ® • Volume 10, Number 7, July 2015 CASE OF THE MONTH SUBMISSION A 39-year-old woman nonsmoker presented in August 2007 with chest wall discomfort. Computed tomography (CT) revealed right upper lobe parenchymal and pleural abnormalities as well as mediastianal lymphadenopathy. Bronchoscopy and mediastinoscopy yielded a(More)
BACKGROUND Immunotherapy in the treatment of metastatic melanoma and renal cell carcinoma can produce durable therapeutic responses, which may improve survival. We aimed to identify clinical characteristics and biomarkers associated with response to high-dose interleukin-2 therapy (IL-2) in patients with metastatic melanoma and renal cell carcinoma treated(More)
BACKGROUND The immune system and vascular endothelial growth factor (VEGF) may be influential in melanoma behavior. We performed a prospective, exploratory analysis in 10 stage III and 22 stage IV melanoma patients to observe factors influencing outcomes. PATIENTS AND METHODS Patients accrued during 2010 and 2011 were treated according to standard(More)
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