Christine Rogez-Kreuz

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IFN-I production is a characteristic of HIV/SIV primary infections. However, acute IFN-I plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this production but primary infection is associated with decreased responsiveness of pDC to TLR 7 and 9 triggering. IFNα production during primary SIV infection(More)
IFN-tau is a non-cytotoxic type I IFN responsible for maternal recognition of the foetus in ruminants. IFN-tau has been found to inhibit HIV replication more strongly than human IFN-alpha, particularly in human monocyte-derived macrophages, without associated toxicity. Ovine IFN-tau uses the same anti-viral cellular pathways as human IFN-alpha in human(More)
IFN-s is a non-cytotoxic type I IFN responsible for maternal recognition of the foetus in ruminants. IFN-s has been found to inhibit HIV replication more strongly than human IFN-a, particularly in human monocyte-derived macrophages, without associated toxicity. Ovine IFN-s uses the same anti-viral cellular pathways as human IFN-a in human macrophages,(More)
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