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Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian(More)
Peptides corresponding to the amino-terminal region of the parathyroid hormone-related protein (PTHrP) of humoral hypercalcemia of malignancy were synthesized. A 34-amino acid peptide, PTHrP(1-34), was two to four times more potent than bovine or human PTH(1-34) in bioassays promoting the formation of adenosine 3',5'-monophosphate (cAMP) and plasminogen(More)
The effects of a monosomy of either the maternally or paternally derived X chromosome in Turner's syndrome (TS) on general neurocognitive status and some executive abilities were assessed using the maximum likelihood estimators for pedigree data. This method increases the power of analysis by accounting for the effect of background heritable variation on a(More)
18 prepubertal growth-hormone (GH)-deficient children were treated with twice-daily subcutaneous injections of a growth-hormone-releasing hormone analogue, GHRH (1-29) NH2. In 12 of the children the height velocity rose on GHRH treatment, and 8 were judged to have shown a worthwhile response to therapy in that their height velocities during the first 6(More)
Peripheral quantitative computed tomography (pQCT) is a non-invasive, low-radiation tool for measuring volumetric bone mineral density. It has potential for use in fracture healing applications; however, the unknown attenuation effects of cast material on peripheral quantitative computed tomography have contributed to its limited use in this area. The(More)
To determine vitamin D deficiency risk and other lifestyle factors in children and teenagers aged 2 – 17 years presenting with fracture to Sunshine Hospital, a clinical observational study was undertaken using convenience sample data collected from children and teenagers aged 2-17 years of age presenting with fracture, for whom consent had been obtained to(More)
Reproductive health knowledge, attitudes and beliefs in young women with type 1 diabetes mellitus aged 15 – 25 years attending a tertiary centre multidisciplinary transition clinic: A descriptive study To assess issues related to the existing reproductive health knowledge, attitudes and beliefs in 15 – 25 year old young women with type 1 diabetes mellitus(More)
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