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Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce information from the cell's identity to its environmental status, thereby(More)
We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs. Classification of the cell lines based solely on the observed patterns of gene expression revealed a correspondence to the ostensible origins of the tumours from(More)
cDNA microarrays and a clustering algorithm were used to identify patterns of gene expression in human mammary epithelial cells growing in culture and in primary human breast tumors. Clusters of coexpressed genes identified through manipulations of mammary epithelial cells in vitro also showed consistent patterns of variation in expression among breast(More)
Merle is a pattern of coloring observed in the coat of the domestic dog and is characterized by patches of diluted pigment. This trait is inherited in an autosomal, incompletely dominant fashion. Dogs heterozygous or homozygous for the merle locus exhibit a wide range of auditory and ophthalmologic abnormalities, which are similar to those observed for the(More)
found that a significant degree of informal geospatial data sharing occurs because of the lack of any formal mechanism, and that there is demand for a mechanism to legitimately share and reuse geospatial research data. Main barriers to more formal geospatial data sharing within the community are: perceived complexity of licensing and digital rights issues(More)
** Note that this DRAFT is subject to revision following completion of some scoping activity and subsequent project-wide discussion of recommended options. Please do not forward beyond immediate circulation. Should you wish a final version, please contact the EDINA Helpdesk, edina@ed.ac.uk, and one will be forwarded. It is anticipated that the final version(More)
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