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  • Helen Skaletsky, Tomoko Kuroda-Kawaguchi, Patrick J Minx, Holland S Cordum, LaDeana Hillier, Laura G Brown +34 others
  • 2003
The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78(More)
  • Ladeana W Hillier, Robert S Fulton, Lucinda A Fulton, Tina A Graves, Kymberlie H Pepin, Caryn Wagner-McPherson +101 others
  • 2003
Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first(More)
  • Ladeana W Hillier, Tina A Graves, Robert S Fulton, Lucinda A Fulton, Kymberlie H Pepin, Patrick Minx +116 others
  • 2005
Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with Wolf-Hirschhorn syndrome, polycystic kidney disease and a form of muscular(More)
Recent work has identified a subset of cells resident in tumors that exhibit properties similar to those found in normal stem cells. Such cells are highly tumorigenic and may be involved in resistance to treatment. However, the genes that regulate the tumor initiating cell (TIC) state are unknown. Here, we show that overexpression of either of the nucleolar(More)
In the past two decades, California's share of the national cut flower market has decreased from 64 percent to 20 percent. California growers' largest competitors are South American growers; Colombia controls 75 percent of the US market. South American growers have several competitive advantages, including the favorable trucking rates they enjoy by(More)
BACKGROUND Eosinophilic esophagitis (EoE) is characterized by the inflammation of the esophagus and the infiltration of eosinophils into the esophagus, leading to symptoms such as dysphagia and stricture formation. Systemic immune indicators like eotaxin and fibroblast growth factor were evaluated for possible synergistic pathological effects. Moreover,(More)
A central retinal vein occlusion (CRVO) can induce an ischemic and hypoxic state with resulting sequelae of macular edema and neovascularization. Many treatment options have been studied. Our review aims to investigate the safety and efficacy of the multiple treatment options of CRVO. A PubMed and Cochrane literature search was performed. Well-controlled(More)
A set of agricultural suppliers with low demands can save on long-haul transportation costs by consolidating their product. We consider a system with stochastic demand and a single consolidation point near the suppliers. We propose a look-ahead heuristic that takes advantage of economies of scale by aiming to ship larger quantities. We experimentally(More)
The rules by which odor receptors encode odors and allow behavior are still largely unexplored. Although large data sets of electrophysiological responses of receptors to odors have been generated, few hypotheses have been tested with behavioral assays. We use a data set on odor responses of Drosophila larval odor receptors coupled with chemotaxis(More)
The full-field electroretinogram (ERG) and visual evoked potential (VEP) are useful tools to assess retinal and visual pathway integrity in both laboratory and clinical settings. Currently, preclinical ERG and VEP measurements are performed with anesthesia to ensure stable electrode placements. However, the very presence of anesthesia has been shown to(More)