Christine Misquitta

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BACKGROUND Alternative splicing (AS) functions to expand proteomic complexity and plays numerous important roles in gene regulation. However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood. (More)
Research indicates that alternative splicing (AS) is a major source contributing to the cellular and functional complexity of metazoan organisms and an important cause of disease if normal splicing is disrupted. While very recent AS sensing technologies such as microarrays and next generation sequencing can potentially be used to understand how AS operates(More)
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Alternative splicing in the central nervous system <p>A microarray analysis provides new evidence suggesting that specific cellular processes in the mammalian CNS are coordinated at the level of alternative splicing, and that a complex(More)
Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation of fundamental biological processes. The extent of AS regulation, and the mechanisms involved, are not well understood. We have developed a custom DNA microarray platform for(More)
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