Learn More
Gametocytes are the agents in malaria transmissible between the vertebrate host and the mosquito vector, and an increase in their incidence would be expected to have a corresponding impact on the prevalence of malaria, particularly in areas of high transmission. The purpose of this study was to determine whether there is an association between the type of(More)
INTRODUCTION Cotrimoxazole (CTX) has been used for half a century. It is inexpensive hence the reason for its almost universal availability and wide clinical spectrum of use. In the last decade, CTX was used for prophylaxis of opportunistic infections in HIV infected people. It also had an impact on the malaria risk in this specific group. OBJECTIVE We(More)
BACKGROUND Safety data regarding exposure to artemisinin-based combination therapy in pregnancy are limited. This prospective cohort study conducted in Zambia evaluated the safety of artemether-lumefantrine (AL) in pregnant women with malaria. METHODS Pregnant women attending antenatal clinics were assigned to groups based on the drug used to treat their(More)
AIMS To determine the population pharmacokinetics of chlorproguanil, dapsone and the active metabolite of chlorproguanil, chlorcycloguanil; and to estimate the duration of parasitocidal activity for chlorpoguanil/dapsone against Plasmodium falciparum isolates of varying sensitivity. METHODS Rich and sparse pharmacokinetic data were collected prospectively(More)
The vitamin A status of 87 children, 7-29 months of age, who were randomly selected from attendees at a pediatric clinic in Ndola, Zambia, were evaluated by the modified relative dose response (MRDR) test. By using a MRDR ratio cut-off point of 0.06, 78% of the children had inadequate vitamin A status. Both male and female children were equally affected. Of(More)
INTRODUCTION Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial was conducted to establish that daily CTX in pregnancy is not inferior to SP(More)
In Zambia, there has been a large scaling up of interventions to control malaria in recent years including the deployment of rapid diagnostic tests (RDTs) to improve malaria surveillance data as well as guide malaria treatment in health facilities. The practical challenge is the impact of RDT results on subsequent management of patients. This study explored(More)
OBJECTIVES To describe and document knowledge and use of anti-malarial drugs at household level in rural Zambia. DESIGN Cross sectional study. SETTING Community based. SUBJECTS Data was collected from 392 male and 415 female respondents. MAIN OUTCOME MEASURES Percentage of respondents knowing the cause of malaria and using modern health facilities.(More)
BACKGROUND European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, and Developing Countries, formed to fund acceleration of new clinical trial interventions to fight the human immunodeficiency virus and(More)