Christine L. Cain

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BACKGROUND The prevalence of meticillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) in canine pyoderma has been increasing in recent years; thus, treatment of these cases has become challenging. HYPOTHESIS/OBJECTIVES To compare treatment outcome (clinical resolution and treatment duration), adverse effects of medication, and concurrent(More)
Staphylococcal antimicrobial resistance presents an emerging challenge for both human and veterinary medical professionals. Infections associated with methicillin- and multidrug-resistant staphylococci are increasingly encountered by veterinarians and are frequently associated with empiric therapeutic failures and limited systemic antimicrobial options.(More)
OBJECTIVE To define clinical differences between coagulase-positive and coagulase-negative Staphylococcus schleiferi infections in dogs and to identify risk factors for the isolation of oxacillin-resistant S schleiferi. DESIGN Retrospective case series. ANIMALS 225 dogs (yielding 225 S schleiferi isolates). PROCEDURES Information obtained from(More)
1 Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2 Dermatology and Allergy,University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA 3 Master of Public Health Program, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 4 Clinical Microbiology, University of(More)
Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization with Staphylococcus species. To examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous(More)
OBJECTIVE To assess the degree of biological similarity (on the basis of genotype determined via pulsed-field gel electrophoresis [PFGE]) between isolates of 2 Staphylococcus schleiferi subspecies (S schleiferi subsp coagulans and S schleiferi subsp schleiferi) in clinical samples obtained from dogs. SAMPLE POPULATION 161 S schleiferi isolates from 160(More)
Staphylococcus schleiferi, a Gram-positive and coagulase-variable organism, is an opportunistic human pathogen and a major cause of skin and soft tissue infections in dogs. Here, we report the first S. schleiferi genome sequence and methylome from four canine clinical isolates.
BACKGROUND Staphylococcus schleiferi is a known pathogen that can cause canine skin and ear infections. The aim of this study was to determine the molecular epidemiology and antimicrobial susceptibility of clinical veterinary isolates from different geographic regions in the United States. HYPOTHESIS It was hypothesized that S. schleiferi would maintain(More)
BACKGROUND Although zinc responsive dermatosis is typically a disorder of Arctic breed dogs, this study identifies similar cutaneous lesions on the face and pressure points of Boston terrier dogs. HYPOTHESIS/OBJECTIVES To document the clinical and histological features of localized parakeratotic hyperkeratosis of Boston terrier dogs, to determine if the(More)
BACKGROUND Sedation is commonly used during intradermal testing (IDT). Morphine and its derivatives have long been avoided because of their histamine-releasing effects. HYPOTHESIS/OBJECTIVES Butorphanol, an opioid agonist/antagonist, will not adversely affect IDT in dogs. ANIMALS Ten client-owned dogs diagnosed with atopic dermatitis. METHODS Dogs(More)