Christine Kestler

Learn More
Intraganglionic laminar endings (IGLEs) represent the major vagal afferent terminals throughout the gut. Electrophysiological experiments revealed a modulatory role of ATP in the IGLE-mechanotransduction process and the P2X2-receptor has been described in IGLEs of mouse, rat and guinea pig. Another purinoceptor, the P2X3-receptor, was found in IGLEs of the(More)
The aetiology of Crohn’s disease is still unknown but mast cells are thought to participate in its pathogenesis. Histological sections show an accumulation of degranulated intestinal mast cells in infl amed areas [1] and their major mediator histamine is increased in the gut lumen of patients with active disease [2]. Furthermore, many symptoms of Crohn’s(More)
  • 1