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Hair-bearing, transitional, and alopecic scalp from three males and one female with progressive pattern alopecia were examined. Ultrastructural studies disclosed measurable thickening of the follicular adventitial sheaths of transitional and alopecic zones compared with those in the non-alopecic zones. This finding was associated with mast cell(More)
OBJECTIVE To determine if changes in histologic parameters obtained from intermittent sampling of the entire block correlated with differences in prognosis and management. DESIGN Prospective analysis of skin biopsy specimens. SETTING Skin pathology laboratory. Patients One hundred consecutive patients with an unequivocal diagnosis of melanoma.(More)
BACKGROUND Seborrheic keratoses have on rare occasion been reported to undergo malignant transformation. OBJECTIVE Our purpose was to examine the incidence and distribution of squamous cell carcinomas (SCCs) in situ arising in clinically banal-appearing seborrheic keratoses. METHODS We prospectively selected such cases over a 6-month period of time from(More)
PURPOSE One of the unique characteristics of cutaneous T-cell lymphoma (CTCL) is its ability to undergo cytologic transformation in which the malignant T cells develop the morphologic appearance of a large-cell lymphoma. Reported to occur in up to 20% of advanced cases, large-cell transformation (LCT) is associated with an aggressive clinical course. Little(More)
We have previously demonstrated that peripheral blood mononuclear cells from patients with Sézary syndrome, the leukemic form of cutaneous T-cell lymphoma which is accompanied by erythroderma and lymphadenopathy, have a Th2 cell cytokine [interleukin 4 (IL-4) and interleukin 5] production pattern. In this study, we extend these observations to demonstrate a(More)
Renal transplant recipients experience a greatly increased frequency of neoplastic skin lesions, including aggressive squamous cell carcinomas. Recent reports suggest that high doses of systemic retinoids may exert a chemotherapeutic and chemoprophylactic effect. Similarly, topical retinoid, especially tretinoin, has also been shown to be anti-tumoragenic(More)
Sorafenib is a multikinase inhibitor newly approved for the treatment of renal cell carcinoma and hepatocellular carcinoma. Multiple cutaneous adverse effects of sorafenib have been described. We present a 68-year-old patient with renal cell carcinoma who developed multiple tender hyperkeratotic papules within weeks of starting sorafenib. The degree of(More)