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- Mona A H Shehata, Andrew E. Teschendorff, +8 authors John Stingl
- Breast Cancer Research
- 2012
The organisation of the mammary epithelial hierarchy is poorly understood. Our hypothesis is that the luminal cell compartment is more complex than initially described, and that an understanding of… (More)
- Richard W. E. Clarkson, Matthew T. Wayland, Jennifer May Lee, Tom C. Freeman, Christine J Watson
- Breast Cancer Research
- 2003
In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale analysis of transcriptional changes… (More)
- Rachel S Chapman, Paula C. C. Lourenço, +6 authors Christine J Watson
- Genes & development
- 1999
Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, Stat3 is specifically activated. To address the function of this signaling… (More)
- Peter A Kreuzaler, Anna D. Staniszewska, +7 authors Christine J Watson
- Nature Cell Biology
- 2011
It is well established that lysosomes play an active role during the execution of cell death. A range of stimuli can lead to lysosomal membrane permeabilization (LMP), thus inducing programmed cell… (More)
- Charles H Streuli, Gwynneth M. Edwards, +4 authors Christine J Watson
- The Journal of biological chemistry
- 1995
Transcription of tissue-specific genes in mammary gland requires signals from both prolactin and basement membrane. Here we address the mechanism by which this specialized extracellular matrix… (More)
- Ekaterini A Kritikou, Andrew S. Sharkey, +4 authors Christine J Watson
- Development
- 2003
STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF is the physiological activator of STAT3, because in involuting mammary glands of Lif(-/-) mice, pSTAT3 is absent… (More)
- Walid T Khaled, Eliot K. C. Read, +6 authors Christine J Watson
- Development
- 2007
Naïve T helper cells differentiate into Th1 and Th2 subsets, which have unique cytokine signatures, activators and transcriptional targets. The Th1/Th2 cytokine milieu is a key paradigm in lineage… (More)
- Sara Pensa, Christine J Watson, Valeria Poli
- Journal of Mammary Gland Biology and Neoplasia
- 2009
The transcription factor Stat3 is essential for timely initiation of post-lactational regression and orchestrates the processes of cell death and tissue remodelling that occur during the first 6 days… (More)
- Stefanie Avril-Sassen, Leonard D. Goldstein, +8 authors Carlos Caldas
- BMC Genomics
- 2009
The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the mammary epithelium. Our aim was… (More)
- Christine J Watson, Walid T Khaled
- Development
- 2008
Mammary gland development occurs through distinctive stages throughout embryonic and pubertal development and reproductive life. At each stage, different signals are required to induce changes in… (More)