Christine H Tsunehara

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OBJECTIVE We investigated the effect of egg feeding in 161 hypercholesterolemic (HC) or combined hyperlipidemic (CHL) free-living subjects taught the NCEP Step I Diet. METHODS Subjects had LDL-C between 3.36 and 4.91 mmol/L (130 and 190 mg/dL). HC subjects had triglyceride concentrations < 75th %-ile, CHL > or = 75th %-ile. Six weeks after instituting the(More)
The transport of fat in the blood stream is approximately twice as fast in women as men. Disease states such as obesity and diabetes are associated with greater lipoprotein abnormalities in women compared with men. A greater increment in cardiovascular disease risk in women is linked to these abnormalities. A greater change in triglyceride level and a(More)
In Seattle, Washington, the prevalence of diabetes was 20% in second-generation (Nisei) Japanese-American men and 16% in Nisei women 45-74 years old, while the prevalence of impaired glucose tolerance (IGT) was 36% in Nisei men and 40% in Nisei women. Hyperglycemia was less and duration of diabetes shorter in women. Related to diabetes and IGT in Nisei were(More)
This is a review of research carried out in Japanese Americans that points towards possible approaches to prevention of type 2 diabetes mellitus. The natural history of type 2 diabetes usually includes both insulin resistance and beta-cell dysfunction. Insulin secretion may compensate for insulin resistance. Alternatively, enhanced insulin sensitivity may(More)
Two drug classes act in the intestine to lower cholesterol. Ezetimibe inhibits cholesterol absorption, whereas bile acid-binding resins enhance cholesterol excretion via enhanced conversion to bile acids. Combining these 2 classes may be beneficial, but cholestyramine binds ezetimibe, and the combined effect of colesevelam hydrochloride and ezetimibe was(More)
We studied the effect of omega-3 fatty acids (omega 3FA) on glucose homeostasis and lipoprotein levels in eight type II (non-insulin-dependent)-diabetic subjects ingesting 8 g/day omega 3FA for 8 wk as marine-lipid concentrate capsules. After omega 3FA supplementation, fasting plasma glucose levels increased 22% (P = .005) and meal-stimulated glucose(More)
The transport of fat in the blood stream is approximately twice as fast in women as men. Disease states such as obesity and diabetes are associated with greater lipoprotein abnormalities in women compared with men. A greater increment in cardiovascular disease risk in women is linked to these abnormalities. A greater change in triglyceride level and a(More)
Second-generation Japanese-American (Nisei) men have rates of non-insulin-dependent diabetes mellitus four times higher than men in Japan, suggesting a role for environmental factors in the etiology of this disease. Dietary intake was assessed for 229 Nisei men with diabetes (DM, n = 78), impaired glucose tolerance (IGT, n = 72), and normal glucose(More)
Japanese American men (n = 124), with normal glucose tolerance (NGT, n = 69) or impaired glucose tolerance (IGT, n = 55) at baseline, were studied for effects of baseline dietary intake and physical activity on glucose tolerance at baseline and at 5-year follow-up. At baseline, both NGT and IGT men with positive family history of diabetes (FH) showed high(More)
Japanese-American men have higher rates of non-insulin-dependent diabetes mellitus and coronary heart disease than same-aged men in Japan. Associations of educational attainment with either non-insulin-dependent diabetes mellitus or coronary heart disease were examined in a sample of 229 second-generation Japanese-American men (aged 45 to 74 years) living(More)
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