Christine H Jones

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The effects on activity rhythms of a daily 30 min opportunity to leave the home cage and hoard seeds from an open field were assessed in Syrian hamsters housed in continuous dim illumination. Six of ten hamsters responded with clear entrainment of their activity rhythms to the hoarding opportunity, as demonstrated by responses to phase shifts and by the(More)
A wire-wrapped wooden dowel was inserted through the wall of the nest compartment of a two-compartment box. There were four conditions. Some lactating female rats were shocked by the dowel when they first touched it, and some were not, after which the dowel was either immediately withdrawn from the chamber or left in place for the duration of the ensuing(More)
The effect of convulsive stimulation during periods of drug exposure on the development of tolerance to the anticonvulsant effects of carbamazepine (CBZ), diazepam (DZP), or sodium valproate (VPA) was studied in three similar experiments. In each experiment, amygdala-kindled rats were assigned to one of three groups: one group received a drug injection(More)
We have collected evidence that a hoarding species of rodent, the Syrian golden hamster (Mesocricetus auratus), uses spatial memory in foraging for food to hoard. Before each trial, we baited the same four arms of a modified seven arm radial maze with sunflower seeds. During the trial we gave each hamster 15-min access to the maze and observed its(More)
RATIONALE Clinical trial design in interstitial lung diseases (ILDs) has been hampered by lack of consensus on appropriate outcome measures for reliably assessing treatment response. In the setting of connective tissue diseases (CTDs), some measures of ILD disease activity and severity may be confounded by non-pulmonary comorbidities. METHODS The(More)
Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT). The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Impact of mutational status on outcomes in myelofibrosis(More)
Association between idiopathic inflammatory myopathies (IIMs) and malignancy is well known and has been extensively reported in the literature. However, in the recent years, several new studies were published allowing us to better understand the clinical characteristics and pathophysiology of cancer-associated IIMs. We conducted a literature review of(More)
The in vitro activity of tigecycline was evaluated against 819 baseline pathogens isolated from 383 patients enrolled in the phase 3 clinical trial investigating the efficacy of tigecycline in hospital acquired pneumonia (HAP). The trials were global, enrolling patients in 27 countries. Tigecycline was active against the most prevalent pathogens in HAP,(More)
Rodger and Rosebrugh (1979) developed a method for identifying sets of rules by which discrete responses are combined to form functional sequences of behavior. In the present study, this so-called finite-state behavioral grammar method was used to analyze the food-hoarding behavior of Syrian golden hamsters (Mesocricetus auratus). Specifically, it was used(More)
Male and female hamsters and gerbils were randomly assigned to one of three groups. The animals were tested under ad lib feeding conditions or food deprived until they had lost either 10% or 20% of their predeprivation body weight. They were given a 30-min. hoarding test for three consecutive days. The results indicated that although food-deprived gerbils(More)