Christine E. Dunn

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Besides its toxicity, groundwater arsenic contamination creates widespread social problems for its victims and their families in Bangladesh. There is, for instance, a tendency to ostracise arsenic-affected people, arsenicosis being thought of as a contagious disease. Within the community, arsenic-affected people are barred from social activities and often(More)
A full-length cDNA encoding a Ca2+-sensing receptor (CaSR) expressed in rat dorsal root ganglia (DRG) was identified using rapid amplification of 5'-cDNA ends and primer extension and then cloned into the plasmid vector pCR3.1. The DNA sequence of the DRG CaSR was 99.9% homologous with published rat kidney CaSR in the coding region and 247 bp upstream of(More)
Air quality information has been made available to the public in the UK since 1990. However, relatively little work has been done to explore the impact of this information and the ways in which it is interpreted and evaluated by members of the public. In this paper, we describe a social constructionist approach to exploring public views on air quality(More)
We used a genetic screening methodology, a human cell line bearing a retinoic-acid-responsive enhanced GFP reporter, and a flow sorter to recover dominant modulators of reporter expression. Four inducers and three suppressors that were fused to the C terminus of a protein scaffold for stability were isolated and their mechanisms of action studied.(More)
OBJECTIVE To assess the effectiveness of 2 interventions in improving the physical activity and well-being of secondary school children. DESIGN A clustered randomised controlled trial; classes, 1 per school, were assigned to 1 of 3 intervention arms or a control group based on a 2×2 factorial design. The interventions were peer-mentoring and participative(More)
Activating mutations in Gαq proteins, which form the α subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling pathways, including PLC/PKC, Rho/Rac, and YAP. Here we show that the small GTPase ARF6 acts as a proximal node of oncogenic Gαq signaling to induce all of these downstream pathways(More)
To perform their work, to carry out the mission-critical goals of their organizations, and to remain on the cutting edge of new research and technologies, public-and private-sector transportation professionals require rapid delivery of reliable information and data. The authoring committee of this report provides strategic advice to the federal and state(More)
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