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Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division.
Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell cycle inheritance is poorly understood. Here, we investigate the biogenesis and propagation ofExpand
Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human
Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNAExpand
UBF an Essential Player in Maintenance of Active NORs and Nucleolar Formation
Nucleolar organizer regions (NORs) are comprised of tandem arrays of ribosomal gene repeats. During interphase, ribosomal genes are transcribed by RNA polymerase I resulting in the formation of aExpand
divisionnuclear domain is formed and propagated through cell Construction of synthetic nucleoli in human cells reveals how a major
Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell cycleinheritance is poorly understood. Here, we investigate the biogenesis and propagation ofExpand