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Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division.
TLDR
It is demonstrated that neo-NORs, UBF-binding site arrays coupled with rDNA transcription units, direct the de novo biogenesis of functional compartmentalized neonucleoli irrespective of their site of chromosomal integration.
Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human
TLDR
This study has demonstrated the functional conservation of eukaryotic HMGB proteins involved in ribosome biogenesis and proposed that Hmo1 has acquired species-specific functions and shares with UBF1 and Sp-Hmo1 an ancestral function to stimulate rDNA transcription.
UBF an Essential Player in Maintenance of Active NORs and Nucleolar Formation
TLDR
It is revealed that UBF, once thought to be restricted to vertebrates, is present in many animal phyla and directs recruitment of many factors required in the early steps of ribosome biogenesis, thus enabling efficient nucleolar reformation.
divisionnuclear domain is formed and propagated through cell Construction of synthetic nucleoli in human cells reveals how a major
TLDR
It is demonstrated that neo-NORs, UBF-binding site arrays coupled with rDNA transcription units, direct the de novo biogenesis of functional compartmentalized neonucleoli irrespective of their site ofchromosomal integration.