Christine Chappard

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The aim of the study was to determine the influence of obesity on bone status in prepubertal children. This study included 20 obese prepubertal children (10.7 ± 1.2 years old) and 23 maturation-matched controls (10.9 ± 1.1 years old). Bone mineral area, bone mineral content (BMC), bone mineral density (BMD), and calculation of bone mineral apparent density(More)
Bone intrinsic strength is conditioned by several factors, including material property and trabecular micro-architecture. Bone mineral density (BMD) is a good surrogate for material property. Architectural anisotropy is of special interest in mechanics-architecture relations and characterizes the degree of directional organization of a material. We have(More)
At present, fracture risk prediction in the individual patient relies chiefly on bone mineral density (BMD) measurements. However, many lines of evidence indicate that the decreased bone strength characteristic of osteoporosis is dependent not only on BMD, but also on other factors, most notably bone microarchitecture. Here, we review available tools for(More)
OBJECTIVES We evaluated the three-dimensional (3D) micro-architecture of subchondral trabecular (Tb) bone in osteoarthritis (OA). Due to high signal-to-noise ratio and high resolution, micro-computed tomography (micro-CT) by synchrotron radiation is considered as the gold standard for bone micro-architecture imaging. DESIGN Subchondral bone were extracted(More)
A new approach to measuring bone properties at the calcaneus using ultrasound parametric imaging has recently emerged. However, an additional source of observer-related error is the substantial regional variations in the pattern of ultrasound parameters. The contribution of intra-observer and inter-observer variability to the coefficient of variation can be(More)
OBJECTIVE Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteocalcin fulfils the same function in(More)
BACKGROUND The degree of anisotropy (DA) on radiographs is related to bone structure, we present a new index to assess DA. METHODS In a region of interest from calcaneus radiographs, we applied a Fast Fourier Transform (FFT). All the FFT spectra involve the horizontal and vertical components corresponding respectively to longitudinal and transversal(More)
PURPOSE To use standard radiographs to determine which combination of co-occurrence textural parameters, geometric measurements, and cortical thickness measurements from femur radiographs provided the best estimate of femoral failure load and to compare these with total hip dual-energy x-ray absorptiometry bone mineral density (BMD) evaluation. MATERIALS(More)
The purpose of this study was to evaluate the usefulness in osteoporosis of a new ultrasound imaging device able to create a parametric image of broadband ultrasound attenuation (BUA) at the os calcis. Three regions of interest were located in the great tuberosity of the os calcis. Precision was evaluated in 37 patients. Calcaneal bone mineral density (BMD)(More)