Fifty years after the implementation of universal newborn screening programs for phenylketonuria, the first disease identified through newborn screening and considered a success story of newborn screening, a cohort of adults with phenylketonuria treated from birth provides valuable information about effects of long-term treatment for inborn errors of… (More)
The concept of information landscapes has been a constant theme in the development of interactive multimedia packages. For the interface and access to this information to be effective and efficient, consideration must be given to the cognitive load placed on the user. Improvement in learning outcomes can be supported by allowing students to focus on… (More)
[This corrects the article DOI: 10.1186/s40608-014-0019-z.].
Glioblastomas have been proposed to be maintained by highly tumorigenic glioblastoma stem cells (GSCs) that are resistant to current therapy. Therefore, targeting GSCs is critical for developing effective therapies for glioblastoma. In this study, we identify the regulatory cascade of the nuclear receptor TLX and the DNA hydroxylase Ten eleven translocation… (More)
BACKGROUND Obesity in Canada is a growing concern, but little is known about the available services for managing obesity in adults. Our objectives were to (a) survey and describe programs dedicated to weight management and (b) evaluate program adherence to established recommendations for care. METHODS We conducted an online environmental scan in 2011 to… (More)
BACKGROUND The majority of obese subjects are treated by primary care physicians (PCPs) who often feel uncomfortable with the management of obesity. In a previous study, we successfully developed, implemented and evaluated an obesity management system based on training and coaching of health professionals of family medicine groups (FMGs) by a team of… (More)
Ovarian cancer is responsible for the majority of gyne-cologic cancer deaths. Despite improvements in surgical approaches and the refinement of first-line cytotoxic combinations, the majority of patients diagnosed with advanced stage ovarian cancer eventually succumb to tumor recurrence. Thus, novel therapeutic approaches are desperately needed for this… (More)