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We have characterized a flat cellular variant of HTLV-1 Tax-transformed rat fibroblasts, 5R, which is unresponsive to all tested NF-kappaB activating stimuli, and we report here its genetic complementation. The recovered full-length cDNA encodes a 48 kDa protein, NEMO (NF-kappaB Essential MOdulator), which contains a putative leucine zipper motif. This(More)
A putative chemokine receptor that we previously cloned and termed LESTR has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains. Cells expressing CD4 became permissive to infection with T-cell-line-adapted HIV-1 strains of the syncytium-inducing phenotype after transfection with LESTR/fusin complementary DNA.(More)
active NF-␬B is released and translocated to the nucleus as a result of the proteolytic degradation of I␬B proteins. Phosphorylation of I␬B␣ on Ser-32 and Ser-36 targets the molecule for degradation by the ubiquitin-26S pro-teasome pathway. While the processes leading to the degradation of the I␬B proteins are relatively well under-de l'Expression Gé nique(More)
Pm: A new hydrogel composed ofiota-carrageenan/polyvinylpyrrolidon (i-cgn/pvp) was tested in rabbit eyes to dctennine its intraocular tolerance and to evaluate its suitability as a vitreous substitute. MefhodF: Aver pars-plana lensectomy and pars-plana vitrectomy 1,Sml of i-cgn/pvp were injected into 4 eyes of 4 rabbitsThe untreated contralateral eyd served(More)
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