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Crystallization and crystallographic data of Escherichia coli maltodextrin prosphorylase
In arAmals, the pyr~doxal-5'-phosphate dependent enzyme phosphorylase (1,4~-D-gMcan: 0rth0ph0sphate a-glueosyl transferase, EC 2.4.1.1) is controUed either by the binding o f specific metaboli tes orExpand
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Infection as a cause of type 1 diabetes?
Purpose of reviewIt is the current opinion that pathogens, such as viruses, are contributing to the development of type 1 diabetes (T1D) in susceptible individuals. This opinion is based onExpand
  • 44
GAD autoantibody affinity in schoolchildren from the general population
Aims/hypothesisSubtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk ofExpand
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Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in theExpand
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Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes
Interleukin (IL)-22 is a cytokine displaying tissue protective and pro-regenerative functions in various preclinical disease models. Anti-bacterial, pro-proliferative, and anti-apoptotic propertiesExpand
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The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
Preproinsulin-specific CD8+ T cells residing in the exocrine pancreas become attracted to islets in type 1 diabetes. Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patientsExpand
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New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existingExpand