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Crystallization and crystallographic data of Escherichia coli maltodextrin prosphorylase
In arAmals, the pyr~doxal-5'-phosphate dependent enzyme phosphorylase (1,4~-D-gMcan: 0rth0ph0sphate a-glueosyl transferase, EC 188.8.131.52) is controUed either by the binding o f specific metaboli tes or… Expand
Infection as a cause of type 1 diabetes?
Purpose of reviewIt is the current opinion that pathogens, such as viruses, are contributing to the development of type 1 diabetes (T1D) in susceptible individuals. This opinion is based on… Expand
GAD autoantibody affinity in schoolchildren from the general population
- Christine Bender, M. Schlosser, U. Christen, A. Ziegler, P. Achenbach
- 18 June 2014
Aims/hypothesisSubtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of… Expand
Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the… Expand
Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes
- Anika Berner, M. Bachmann, Christine Bender, J. Pfeilschifter, U. Christen, H. Mühl
- Biology, Medicine
- Front. Pharmacol.
- 12 January 2016
Interleukin (IL)-22 is a cytokine displaying tissue protective and pro-regenerative functions in various preclinical disease models. Anti-bacterial, pro-proliferative, and anti-apoptotic properties… Expand
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
- Christine Bender, T. Rodriguez-Calvo, N. Amirian, K. Coppieters, M. V. von Herrath
- Biology, Medicine
- Science Advances
- 1 October 2020
Preproinsulin-specific CD8+ T cells residing in the exocrine pancreas become attracted to islets in type 1 diabetes. Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients… Expand
Faculty Opinions recommendation of Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes.
Absence of CXCL10 prolongs islet graft survival in an autoimmune mouse model for Type 1 Diabetes
New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing… Expand