Christine B Warren

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Topical 5-aminolevulinic acid (ALA) is widely used in photodynamic therapy (PDT) of actinic keratoses (AK), a type of premalignant skin lesion. However, the optimal time between ALA application and exposure to light has not been carefully investigated. Our objective is to study the kinetics of protoporphyrin IX (PpIX) accumulation in AK after short contact(More)
Neonatal hyperbilirubinaemia, of any cause, is potentially dangerous and may produce kernikterus. The standard method of treatment is by exchange transfusion, carried out as often as necessary to keep the serum bilirubin below an arbitrary danger level of between 20 and 30 mg./100 ml. There is, however, no clear evidence that any absolute value in serum(More)
The CCAAT/Enhancer Binding Proteins (C/EBPs) are a family of leucine-zipper transcription factors that regulate physiological processes such as energy metabolism, inflammation, cell cycle, and the development and differentiation of several tissues including skin. Recently, a role for C/EBPs in tumor cell proliferation and differentiation has been proposed,(More)
BACKGROUND Pain during topical aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) limits the use of this treatment of skin diseases. OBJECTIVE We sought to summarize the effectiveness of interventions to reduce ALA-PDT-related pain, and to explore factors contributing to pain induction. METHODS A PubMed search was performed to identify all(More)
REFERENCES 1. De Groot A, Conemans JMH. Systemic allergic contact dermatitis from intravesical instillation of the antitumor antibiotic mitomycin C. Contact Dermatitis 1991;24:201-9. 2. Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C. Contact Dermatitis 2000;42:74-6. 3. Justiniano H, Berlingeri-Ramos(More)
The clinical manifestations of Wilson's disease are believed to be due to the accumulation of toxic amounts of copper within the body. The primary aim of treatment is to remove these, usually by giving chelating agents that will combine with the copper and be excreted in the urine. The most effective of these therapeutic agents is penicillamine (Walshe,(More)
Ultrastructural evaluation of skin biopsies has been utilized for diagnosis of mitochondrial disease. This study investigates how frequently skin biopsies reveal mitochondrial abnormalities, correlates skin and muscle biopsy findings, and describes clinical diagnoses rendered following the evaluation. A retrospective review of surgical pathology reports(More)
Photodynamic therapy (PDT), using topical aminolevulinic acid (ALA), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and in situ squamous cell carcinoma. While there is a wide range of neoplastic and non-neoplastic skin diseases for which ALA-PDT is used in adults, there(More)