Christine Alexander

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Expansions of a (GCN)10/polyalanine tract in the Poly(A) Binding Protein Nuclear 1 (PABPN1) cause autosomal dominant oculopharyngeal muscular dystrophy (OPMD). In OPMD muscles, as in models, PABPN1 accumulates in intranuclear inclusions (INIs) whereas in other diseases caused by similar polyalanine expansions, the mutated proteins have been shown to(More)
Because the androgen and estrogen nuclear hormone receptors are subject to acetylation, we speculated that the nuclear thyroid hormone receptor-beta1 (TRbeta1), another superfamily member, was also subject to this posttranslational modification. Treatment of 293T cells that contain TRbeta1(wt) with l-thyroxine (T4)(10(-7)M, total concentration) resulted in(More)
At a time when the demand for people with IT skills is at an all-time high, the number of U.S. information systems and computer science students has taken a nose dive. There are two phenomena influencing this trend, namely an overall decline in male enrollment in liberal arts colleges and universities and a decline in enrollment of females in(More)
This silver crescent was the ear, or handle, of a shallow dish. Such another dish was once found in the harbor at Bizerta in Tunisia, during dredging operations; it is circular, with two crescent handles, weighs nearly ten pounds, and is about a yard across, over all. If the dish to which our handle belonged was of the same pattern, its span was 21 2(More)
Previously published Photo Quizzes are now featured in a mobile app. Get more information at http:// www.aafp.org/afp/apps. A 59-year-old man presented with fever, chills, and a pruritic rash that had generalized peeling and underlying redness. The rash began one month prior as small papules on his arms and then spread across his entire body, including his(More)
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