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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

• Beata Wójciak-Stothard, Vahitha B. Abdul-Salam, +14 authors Martin R Wilkins
• Circulation
• 2014

BACKGROUND Chloride intracellular channel 4 (CLIC4) is highly expressed in the endothelium of remodeled pulmonary vessels and plexiform lesions of patients with pulmonary arterial hypertension. CLIC4… (More)

Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism.

• Christina Lisk, Doug Kominsky, +5 authors David C Irwin
• American journal of respiratory cell and…
• 2013

The release of hemoglobin (Hb) with hemolysis causes vascular dysfunction. New evidence implicates Hb-induced NF-κB and hypoxia inducible factor (HIF) activation, which may be under the control of a… (More)

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin…

• David C Irwin, Jin Hyen Baek, +8 authors Paul Bühler
• Free radical biology & medicine
• 2015

Haptoglobin (Hp) is an approved treatment in Japan for trauma, burns, and massive transfusion-related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to… (More)

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.

• Paul Bühler, Jin Hyen Baek, +8 authors David C Irwin
• American journal of physiology. Lung cellular and…
• 2012

Cell-free hemoglobin (Hb) exposure may be a pathogenic mediator in the development of pulmonary arterial hypertension (PAH), and when combined with chronic hypoxia the potential for exacerbation of… (More)

Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.

• Christina Lisk, J M Mccord, +6 authors David C Irwin
• Free radical biology & medicine
• 2013

Reactive oxygen species (ROS) formed during acute high altitude exposure contribute to cerebral vascular leak and development of acute mountain sickness (AMS). Nuclear factor (erythroid-derived… (More)

Nrf 2 Activation : A potential strategy for the prevention of Acute Mountain Sickness

• Christina Lisk, J M Mccord, +6 authors David C Irwin
• 2014

Introduction—Reactive oxygen species (ROS) formed during acute high altitude exposure contributes to cerebral vascular leak and development of acute mountain sickness (AMS). Nuclear factor… (More)

A retrospective study of acute mountain sickness on Mt. Kilimanjaro using trekking company data.

• Paul Eigenberger, Anna V. Faino, +7 authors David Irwin
• Aviation, space, and environmental medicine
• 2014

BACKGROUND High altitude illnesses (HAI) are a risk factor for any individual who is exposed to a significant increase in altitude. To learn more about the epidemiology of HAI, we sought to determine… (More)

Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

• Zoe L. Loomis, Paul Eigenberger, +9 authors David C Irwin
• PloS one
• 2017

It is now well established that both inherited and acquired forms of hemolytic disease can promote pulmonary vascular disease consequent of free hemoglobin (Hb) induced NO scavenging, elevations in… (More)

Toll-Like Receptor Adjuvants Influence Antigen Deposition on Follicular Dendritic Cells

• Kidest Assefa-McNeil, Christina Lisk, Danielle Antos, Rachel Yuen, Dr. Lee Wetzler
• 2018

Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

• Zoe L. Loomis, Paul Eigenberger, +9 authors David C Irwin
• PloS one
• 2017

[This corrects the article DOI: 10.1371/journal.pone.0171219.].

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