Christina Kloepping

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OBJECTIVE The aim of the study was to assess the occurrence of triggered activity and automaticity in ventricular trabeculae from failing human hearts and normal and failing rabbit hearts during exposure to a normal and altered extracellular environment. METHODS Ventricular trabeculae were harvested from failing human hearts (from patients undergoing(More)
BACKGROUND Animal studies have shown that the Ca(2+)-activated Cl(-) current (I(Cl(Ca))) and the Na(+)/Ca(2+) exchange current (I(Na/Ca)) contribute to the transient inward current (I(ti)). I(ti) is responsible for the proarrhythmic delayed afterdepolarizations (DADs). We investigated the ionic mechanism of I(ti) and DADs in human cardiac cells. METHODS(More)
Pulmonary hypertension (PH) is a disease with a poor prognosis characterized by a vascular remodeling process and an increase in pulmonary vascular resistance. While a variety of reports demonstrated that exercise training exerts beneficial effects on exercise performance and quality of life in PH patients, it is not known how physical exercise affects(More)
BACKGROUND Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling and increased pulmonary vascular resistance. Chronic alveolar hypoxia in animals is often used to decipher pathways being regulated in PH. Here, we aimed to investigate whether chronic hypoxia-induced PH in mice can be reversed by reoxygenation and(More)
Friederike Christine Weisel, PhD; Christina Kloepping, DVM; Alexandra Pichl, PhD; Akylbek Sydykov, MD, PhD; Baktybek Kojonazarov, MD, PhD; Jochen Wilhelm, PhD; Markus Roth, PhD; Karen Marie Ridge, PhD; Kazuei Igarashi, PhD; Kazuhiro Nishimura, PhD; Wolfgang Maison, PhD; Claudia Wackendorff ; Walter Klepetko, MD; Peter Jaksch, MD; Hossein Ardeschir Ghofrani,(More)
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