Christina Han

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OBJECTIVE To examine the association between route of delivery and neonatal outcomes in a large, diverse cohort of preterm, appropriate-for-gestational-age neonates. METHODS This is a retrospective cohort study examining New York City birth data for 1995-2003 linked to hospital discharge data. Data were limited to singleton, live-born, cephalic neonates(More)
Bacterial infection-associated inflammation is thought to be a major cause of preterm premature rupture of membranes. Proinflammatory cytokines, such as interleukin 1B (IL1B), can weaken fetal membranes (FM) by upregulating matrix metalloproteinases and inducing apoptosis. The mechanism by which infection leads to inflammation at the maternal-fetal(More)
OBJECTIVE Low molecular weight (LMW) heparin, with or without aspirin (acetylsalicylic acid [ASA]), is used to prevent complications in antiphospholipid syndrome in pregnancy. Our objective was to elucidate the actions of low-dose LMW heparin and ASA on basal and antiphospholipid antibody-induced modulation of trophoblast function. METHODS The human(More)
BACKGROUND Spontaneous ovarian hyperstimulation syndrome is a rare occurrence in pregnancy. This is a case of pregnancy with spontaneous ovarian hyperstimulation syndrome, uncontrolled hypothyroidism, elevated human chorionic gonadotropin (hCG), deep vein thrombosis, and Rh isoimmunization. CASE An African-American woman in her mid-30s, gravida 3 para 0,(More)
OBJECTIVE To estimate whether blood-contaminated amniotic fluid affects the performance of white blood cell (WBC) count in diagnosing intraamniotic inflammation and infection. METHODS Three hundred fifty-seven consecutive women pregnant with singletons undergoing amniocentesis to rule out infection were enrolled prospectively. A "bloody tap" was defined(More)
PROBLEM  Women with antiphospholipid antibodies (aPL) are at risk of miscarriage and pre-eclampsia, obstetrical disorders associated with reduced trophoblast invasion and spiral artery transformation. aPL target the placenta by binding beta(2) -glycoprotein I (β(2) GPI) on the trophoblast. In this study, we determined whether aPL alter the trophoblast(More)
OBJECTIVE This study was undertaken to evaluate the relationship between chorionic villus sampling at 10-13 weeks' gestational age and hypertensive disorders of pregnancy. STUDY DESIGN The prevalence of hypertensive disorders of pregnancy in women with singleton gestations, undergoing transcervical or transabdominal chorionic villus sampling between 10(More)
Chronic, subacute decidual hemorrhage (ie, abruptio placenta and retrochorionic hematoma formation) is an important contributor to preterm parturition. Such hemorrhage induces thrombin from decidual tissue factor, which plays a pivotal role in the development of preterm premature rupture of membranes and preterm delivery by acting through protease-activated(More)
OBJECTIVE To compare the incidence of wound complications between suture and staple skin closure after cesarean delivery. METHODS This prospective, randomized clinical trial conducted at three hospitals in the United States between 2010 and 2012 included women undergoing cesarean delivery at 23 weeks of gestation or greater through a low-transverse skin(More)
OBJECTIVES This study aimed to determine whether administration of lamivudine to pregnant women with chronic hepatitis B in the third trimester is a cost-effective strategy in preventing perinatal transmission. STUDY DESIGN We developed a decision analysis model to compare the cost-effectiveness of 2 management strategies for chronic hepatitis B in(More)