Christina Ferreira

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As an important step in the nuclear transfer (NT) procedure, we evaluated the effect of three different treatments for oocyte activation on the in vitro and in vivo developmental capacity of bovine reconstructed embryos: (1) strontium, which has been successfully used in mice but not yet tested in cattle; (2) ionomycin and 6-dimethylaminopurine (6-DMAP), a(More)
An additional degree of freedom is introduced to fractional-Fourier-transform systems by use of anamorphic optics. A different fractional Fourier order along the orthogonal principal directions is performed. Alaboratory experimental system shows preliminary results that demonstrate the proposed theory. Applications such as anamorphic fractional correlation(More)
The mechanisms controlling the outcome of donor cell-derived mitochondrial DNA (mtDNA) in cloned animals remain largely unknown. This research was designed to investigate the kinetics of somatic and embryonic mtDNA in reconstructed bovine embryos during preimplantation development, as well as in cloned animals. The experiment involved two different(More)
Cardinal is an R package for statistical analysis of mass spectrometry-based imaging (MSI) experiments of biological samples such as tissues. Cardinal supports both Matrix-Assisted Laser Desorption/Ionization (MALDI) and Desorption Electrospray Ionization-based MSI workflows, and experiments with multiple tissues and complex designs. The main analytical(More)
Alteration of maternal lipid metabolism early in development has been shown to trigger obesity, insulin resistance, type 2 diabetes and cardiovascular diseases later in life in humans and animal models. Here, we set out to determine (i) lipid composition dynamics in single oocytes and preimplantation embryos by high mass resolution desorption electrospray(More)
In vitro-matured (IVM) bovine oocytes were activated with single and combined treatments of strontium (S), ionomycin (I) and 6-DMAP (D). Using oocytes IVM for 26 h, we observed that activation altered cell cycle kinetics (faster progression, MIII arrest, or direct transition from MII to pronuclear stage) when compared to in vitro fertilization. The effect(More)
The expanding use of optical communication by means of optical fibers and the situation of drastically increasing amounts of data to be transmitted urge the exploration of novel systems permitting the transmission of large amounts of spatial information by fiber with smaller spatial resolution. An optical encoding and decoding system is suggested for(More)
We introduce a modification of the nonlinear morphological correlation for optical rotation-invariant pattern recognition. The high selectivity of the morphological correlation is conserved compared with standard linear correlation. The operation performs the common morphological correlation by extraction of the information by means of a circular-harmonic(More)
Polybromo-1 (PBRM1) is a component of the PBAF (Polybromo-associated-BRG1- or BRM-associated factors) chromatin remodeling complex and is the second most frequently mutated gene in clear-cell renal cell Carcinoma (ccRCC). Mutation of PBRM1 is believed to be an early event in carcinogenesis, however its function as a tumor suppressor is not understood. In(More)