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Septins are a family of GTP-binding proteins considered to be cytoskeletal elements because they self-assemble into filaments and other higher-order structures in vivo. In budding yeast, septins establish a diffusion barrier at the bud neck between a mother and daughter cell, promote membrane curvature there, and serve as a scaffold to recruit other(More)
SEAONC and its Board assume no liability for its accuracy or for the opinions expressed herein. The material presented in this document should not be used or relied upon for any specific application without competent examination and verification of its accuracy, suitability, and applicability by qualified professionals. Users of information from this(More)
PURPOSE Geriatric issues in cancer are becoming prominent. Depression is a significant concern for both the elderly and patients with cancer, yet identifying depression in these patients is difficult and often leads to under-recognition. We conducted a systematic review to determine which depression instruments are appropriate for use in geriatric patients(More)
The Brennan Center for Justice, founded in 1995, unites thinkers and advocates in pursuit of a vision of inclusive and effective democracy. The free expression policy project founded in 2000, provides research and advocacy on free speech, copyright, and media democracy issues. fepp joined the Brennan center in 2004. 2006. This work is covered by a creative(More)
That cardiac regeneration is remotely feasible elicits thoughts of curing one of the most debilitating of human diseases. The term stem cell brings to the surface many hopes, and concerns, among physicians and the public alike, both of which have come to expect frequent advances in medical therapeutics. The evolution of public opinion toward embryonic stem(More)
Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is thought to contribute to metastasis and drug resistance. Fibronectin is an elastic, multi-modular protein made up of individually folded domains, some of which can(More)
In the United States today, more than 2 million women live as breast cancer survivors. As the number of cancer survivors grows, the unique long-term side effects of cancer treatment and aging play an increasingly prominent role in the routine care of these patients. Of special concern are the short- and long-term effects of sex hormone deprivation. This(More)
To evaluate the association between the hematopoietic cell transplantation-comorbidity index (HCT-CI) and the recently developed age-adjusted HCT-CI (HCT-CI/age) and transplant outcomes in the setting of CD34-selected allogeneic HCT, we analyzed a homogeneous population of patients undergoing allogeneic HCT with CD34-selected grafts for acute myeloid(More)
The fibronectin matrix provides mechanical and biochemical information to regulate homeostatic and pathological processes within tissues. Fibronectin consists of independently-folded modules termed Types I, II and III. In response to cellular contractile force, Type III domains unfold to initiate a series of homophilic binding events which result in the(More)
Ex vivo CD34+-selected T cell depletion (TCD) has been developed as a strategy to reduce the incidence of graft-versus-host disease (GVHD) after allogeneic (allo) hematopoietic stem cell transplantation (HSCT). Clinical characteristics, treatment responses, and outcomes of patients developing acute (aGVHD) and chronic GVHD (cGVHD) after TCD allo-HSCT have(More)
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