Christina A. Minami

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Notorious for its poor prognosis and aggressive nature, triple-negative breast cancer (TNBC) is a heterogeneous disease entity. The nature of its biological specificity, which is similar to basal-like cancers, tumors arising in BRCA1 mutation carriers, and claudin-low cancers, is currently being explored in hopes of finding the targets for novel biologics(More)
BACKGROUND Physical examination (PE), mammography (MG), breast magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (PET), and pathologic evaluation are used to assess primary breast cancer. To the authors' knowledge, their accuracy has not been well studied in patients receiving neoadjuvant chemotherapy. Accuracies of each(More)
BACKGROUND Preclinical studies have shown the anticancer potential of HMG-CoA reductase enzyme inhibitors (statins), whereas epidemiologic studies remain controversial. Because lipophilic statins show preclinical anticancer activity against hormone receptor [estrogen receptor (ER)/progesterone receptor (PR)]-negative breast cancer models, we explored the(More)
Current guidelines recommend postmastectomy radiotherapy (PMRT) for patients with ≥4 positive lymph nodes and suggest strong consideration of PMRT in those with 1–3 positive nodes. These recommendations were incorporated into a Commission on Cancer quality measure in 2014. However, national adherence with these recommendations is unknown. Our objectives(More)
BACKGROUND Northwestern Memorial Hospital (NMH) was historically a poor performer on the venous thromboembolism (VTE) outcome measure. As this measure has been shown to be flawed by surveillance bias, NMH embraced process-of-care measures to ensure appropriate VTE prophylaxis to assess healthcare-associated VTE prevention efforts. OBJECTIVE To evaluate(More)
Physicians often shy away from conversations with patients regardingpoorprognoses.Evenwhenphysiciansdogivepatients specificprognoses, theymayconveyoverlyoptimistic information.1Giving patients potentially misleading information violates cultural norms and ethical standards. Physicians often believe that they should always strive to have transparent and(More)
RESEARCH LETTER Association BetweenHospital Characteristics and Performance on theNewHospital-Acquired Condition Reduction Program’s Surgical Site InfectionMeasures The Centers for Medicare and Medicaid Services HospitalAcquired Condition (HAC) Reduction Program implemented financial penalties for poorly performing hospitals in federal fiscal year 2015.(More)