Christin Weisser

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The growth of melanocytes, the pigment-producing cells of the skin, normally is restricted to the epidermis. Transformed melanocytes, which have invaded the dermis, however, have gained the ability to grow in this new environment and to counteract apoptosis induced by the dermal connective tissue. The expression of genes contributing to the survival of(More)
Malignant melanoma is a cancer whose incidence is rising rapidly, but the mechanism by which normal melanocytes become malignant in vivo is still little understood. In the course of melanoma progression, a fraction of cells often becomes depigmented, which reflects the loss of the balance between mitogenic activities and differentiation in those pigment(More)
Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. We reported recently that the melanoma inducing EGFR-related receptor Xmrk specifically induces constitutive activation of STAT5 in fish(More)
BACKGROUND Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established adjuvant immunotherapy for melanoma of advanced stage. IFNalpha is a potent inhibitor of melanoma cell proliferation, and the signal transducer and activator of(More)
Polar stratospheric clouds (PSC) have been observed in early winter (December 2002) during the SOLVE II/Vintresol campaign, both from balloons carrying comprehensive instrumentation for measurements of chemical composition, size distributions, and optical properties of the particles, as well as from individual backscatter soundings from 5 Esrange and(More)
Synoptic scale polar stratospheric clouds (PSCs) that formed without the presence of mountain lee waves were observed in early December 2002 from Kiruna/Sweden using balloon-borne instruments. The physical, chemical, and optical properties of the particles were measured. Within the PSC solid particles existed whenever the temperature was below the(More)
Fritz König (1866-1952) was 1918-1935 ordinary professor of surgery at the University of Wuerzburg. A main interest of his work was the technique and indication of osteosynthesis. Since 1900 he investigated methods (wire suture, intra- and extramedullary splint, external fixator, plate) and materials (ivory, steel; wire, screws). All his life he aimed to(More)