Christie M Loiacono

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Herpes simplex virus type 1 (HSV-1) immediate-early (IE) proteins are required for the expression of viral early and late proteins. It has been hypothesized that host neuronal proteins regulate expression of HSV-1 IE genes that in turn control viral latency and reactivation. We investigated the ability of neuronal proteins in vivo to activate HSV-1 IE gene(More)
A distinct strain of scrapie identified in sheep of Norway in 1998 has since been identified in numerous countries throughout Europe. The disease is known as Nor98 or Nor98-like scrapie, among other names. Distinctions between classic scrapie and Nor98 scrapie are made based on histopathology and immunodiagnostic results. There are also differences in the(More)
Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to test whether sensory ganglia neurons could(More)
Shen HG, Loiacono CM, Halbur PG, et al. Age-dependent susceptibility to porcine circovirus type 2 infections is likely associated with declining levels of maternal antibodies. Summary Objectives: To investigate the relationships between age, porcine circovirus type 2 (PCV2) viremia, and pathologic lesions by evaluating the age of porcine circovirus(More)
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