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Chronic intrathecal immunoglobulin (Ig) production is a hallmark of multiple sclerosis characterized by the presence of oligoclonal IgGs and, in addition, polyspecific recognition of different pathogens such as measles, rubella and herpes zoster virus. While the antigen specificity of the oligoclonal IgGs in multiple sclerosis is largely unknown, the(More)
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of a large set of sarcomeric proteins. We identify the(More)
We formulate the well-known economic lot scheduling problem (ELSP) with sequence dependent setup times and costs as a semi-Markov decision process. Using an affine approximation of the bias function, we obtain a semi-infinite linear program determining a lower bound for the minimum average cost rate. Under a very mild condition, we can reduce this problem(More)
There has been an increasing emphasis on health care efficiency and costs and on improving quality in health care settings such as hospitals or clinics. However, there has not been sufficient work on methods of improving access and customer service times in health care settings. The study develops a framework for improving access and customer service time(More)
We consider a patient admission problem to a hospital with multiple resource constraints (e.g. OR and beds) and a stochastic evolution of patient care requirements across multiple resources. There is a small but significant proportion of emergency patients who arrive randomly and have to be accepted at the hospital. However, the hospital needs to decide(More)
The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we present a genome-wide fosmid library of 10000 GFP-tagged clones, comprising tagged genes and most of their regulatory information. For 880(More)