Christiana A Okonkwo

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Chlorpheniramine (CP), a histamine H1-receptor antagonist, enhances the efficacy of chloroquine (CQ) in acute uncomplicated falciparum malaria. The effects of this combination therapy on the pharmacokinetic disposition of CQ is, however, unpredictable. A standard treatment with 25 mg CQ base per kg bodyweight was orally administered over 3 days, alone or in(More)
This study determined the effects of acute cypermethrin toxicity in the rat and its dose-response characteristics The intraperitoneal LD50 of cypermethrin from the study was 44.0 mg/kg body weight. The symptoms of toxicity were muscular weakness, swaying gait and respiratory distress; pallor and prostration occurred at higher doses and convulsions preceded(More)
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