Christian Zürcher

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Synthetic modification of cyclosporin A at P3-P4 positions led to the discovery of NIM258, a next generation cyclophilin inhibitor with excellent anti-hepatitis C virus potency, with decreased transporter inhibition, and pharmacokinetics suitable for coadministration with other drugs. Herein is disclosed the evolution of the synthetic strategy to from the(More)
A factor causing dark pigmentation of the abdomen in females ofD. melanogaster has been located on the third chromosome, at locus69,8±0,4 morgans. Among 19,050 flies no crossing over was found to occur between this factor (derived from a wild population) and the geneebony. These results and those of segregation experiments point toward an allelism of the(More)
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