Christian Wuthrich

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The polyomavirus JC (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy (PML). JCV remains quiescent in kidneys, where it displays a stable archetypal regulatory region (RR). Conversely, rearranged JCV RR, including tandem repeat patterns found in the central nervous system (CNS) of PML patients, have been associated with(More)
The rapid development of scanning and measuring hardware for medical imaging and for scientiic experiments, the introduction of animation techniques into common use have created the need to understand n-dimensional raster geometry, where n > 3. After a brief review of continuous geometry in R n , this paper presents the discrete regular structure called a(More)
OBJECTIVE To determine the frequency of hyperintense cortical signal (HCS) on T1-weighted precontrast magnetic resonance (MR) images in progressive multifocal leukoencephalopathy (PML) patients, its association with seizure risk and immune reconstitution inflammatory syndrome (IRIS), and its pathologic correlate. METHODS We reviewed clinical data(More)
JC virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause meningitis has not yet been demonstrated. We report a case of aseptic meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency virus-seronegative patient. Brain imaging(More)
7053-7065. (41) Howard, J. A.; Scaiano, J. C. Landolt Bornstein New Series, Kinetic Rate Constants of Radical Reactions in Solution: Part d , Oxyl-, Peroxyl-, and Related Radicals; SpringerVerlag: Berlin-Heidelberg, 1984; Series II/13d. (42) Paris, D. F.; Wolfe, N. L.; Steen, W. C.; Baughman, G. L. Appl. Enuiron. Microbiol. 1983, 45(3), 1153-1155. (43)(More)
We explain how to use results from Iwasawa theory to obtain information about p-parts of Tate-Shafarevich groups of specific elliptic curves over Q. Our method provides a practical way to compute #X(E/Q)(p) in many cases when traditional p-descent methods are completely impractical and also in situations where results of Kolyvagin do not apply, e.g., when(More)
Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia.(More)