Christian Werner

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BACKGROUND The underlying molecular mechanisms of the vasculoprotective effects of physical exercise are incompletely understood. Telomere erosion is a central component of aging, and telomere-associated proteins regulate cellular senescence and survival. This study examines the effects of exercising on vascular telomere biology and endothelial apoptosis in(More)
OBJECTIVES The purpose of this study was to study the underlying molecular mechanisms of the protective cardiac effects of physical exercise. BACKGROUND Telomere-regulating proteins affect cellular senescence, survival, and regeneration. METHODS C57/Bl6 wild-type, endothelial nitric oxide synthase (eNOS)-deficient and telomerase reverse transcriptase(More)
A major drawback of using SOAP for application integration is its enormous demand for network bandwidth. Compared to classical approaches like Java-RMI and CORBA, SOAP messages typically cause more than three times more network traffic. In this paper we will give a detailed survey of state of the art binary encoding strategies for SOAP and introduce a new(More)
PPAR-gamma agonists (thiazolidinediones, TZDs) may improve endothelial function independently of insulin sensitizing. Bone marrow-derived endothelial progenitor cells (EPC) contribute to neoangiogenesis. Mice were treated with pioglitazone, 20mg/kg/day for 10 days. Treatment with TZD upregulated circulating Sca-1/VEGFR-2 positive EPC in the blood(More)
OBJECTIVE Peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists (thiazolidinediones [TZDs]) are used for the treatment of diabetes. Bone marrow-derived endothelial progenitor cells (EPCs) improve vascular function and predict cardiovascular risk. The effect of pioglitazone therapy on EPCs was examined. RESEARCH DESIGN AND METHODS AND(More)
In environments with limited network bandwidth or resource-constrained computing devices the high amount of protocol overhead caused by SOAP is disadvantageous. Therefore, recent research work concentrated on more compact, binary representations of XML data. However, due to the special characteristics of SOAP communication most of these approaches are not(More)
Within the past years the Web service technology emerged into more and more fields of application. In some cases the classical approach of using HTTP as a transport binding for SOAP seems no longer adequate. As a full scale application protocol HTTP causes a high amount of protocol overhead and is too inflexible for many Web Service scenarios. In this paper(More)
PURPOSE OF REVIEW In neurosurgery, anesthesiologists and surgeons focus on the same target - the brain. The nature of anesthetics is to interact with brain physiology, leading to favorable and adverse effects. Research in neuroanesthesia over the last three decades has been dedicated to identifying the optimal anesthetic agent to maintain coupling between(More)
Bispectral Index (BIS) has been marketed as a measure of the hypnotic component of anesthesia and is recommended as a guide for the administration of hypnotic drugs during anesthesia. BIS values between 40 and 60 are recommended for surgery under general anesthesia. This study investigates whether a BIS baseline between 50 and 60 prevents awareness reaction(More)