Christian Wüster

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BACKGROUND Analysis of insulin-like growth factor I in serum (S-IGF-I) is an integral component in the diagnosis of GH-related disorders and is going to be of interest in the diagnosis and follow-up of many disorders. The objective of the present study was to develop cross-sectional reference values for S-IGF-I measured by an automated chemiluminescence(More)
OBJECTIVES Postmenopausal osteoporosis is becoming a major problem for healthcare institutions as it has a growing social and economic impact. The incidence of osteoporotic fractures is constantly increasing due to the increase in life expectancy. The gynaecologist plays an important role in establishing a "biological zero" in each perimenopausal patient,(More)
OBJECTIVE To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of GH replacement. DESIGN Data from a(More)
Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with RET exon 10 mutations for clinical-risk profiles. Presentation, age-dependent(More)
OBJECTIVE Several studies documented metabolic and psychological benefits of GH substitution in deficient adults, most of them suffering from benign pituitary adenomas. Since GH substitution is considered to promote tumour regrowth, adequate treatment is performed with some reservation. Therefore, we aimed to elucidate the effect of GH replacement therapy(More)
Die multiple endokrine Neoplasie (MEN) Typ 1 zeigt neben den typischen Veränderungen an Nebenschiddrüsen, Hypophysenvorderlappen und Tumoren des Magen/Darm-Traktes klinisch vielfältige Varianzen. Bei der hier vorgestellten 68jährigen Patientin ist seit 18 Jahren eine MEN-1 (Gastrinom, pHPT, positive Familienamnese für endokrine Tumoren) bekannt. Zusätzlich(More)
We report on a 30-year-old man with azoospermia, primary hypogonadism and minor dysmorphic features who carried a balanced insertional chromosome translocation inv ins (2p24;4q28.3q31.22)de novo. Molecular cytogenetic analyses of the chromosome breakpoints revealed the localization of the breakpoint in 4q28.3 between BACs RP11-143E9 and RP11-285A15, an(More)
□Background: In order to test the validity of vertebral morphometry for the assessment of prevalent vertebral osteoporotic fractures, we examined the association between vertebral deformities and bone mineral density (BMD). □Method: The study population consisted of 595 postmenopausal women and 581 men aged 50 to 82 years who participated in the baseline(More)
There is a great need to introduce methods to determine bone fragility in outpatient settings for chronically GC-treated patients which are easy to use, reasonably inexpensive, precise and have a high sensitivity and specificity to detect patients at risk for fractures. DXA and QUS have both been shown to predict hip fracture rates independently in(More)