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Abstract Migration of microglial cells towards damaged tissue plays a key role in central nervous system regeneration under pathological conditions. Using time lapse video microscopy we show that lysophosphatidic acid (LPA) enhances chemokinetic migration of murine microglial cells. In the presence of 1 micro m LPA, the mean migration rate of microglial(More)
OBJECTIVES To review, summarise, and compare the evidence for effectiveness of screening sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer occurrence and deaths. DESIGN Systematic review and meta-analysis of randomised controlled trials and observational studies. DATA SOURCES PubMed, Embase, and Web of Science. Two(More)
BACKGROUND Colorectal cancer (CRC) is one of the most commonly diagnosed cancers. Circulating microRNAs (miRNAs) have been suggested as potentially promising markers for early detection of CRC. We aimed to identify and evaluate a panel of miRNAs that might be suitable for CRC early detection. METHODS MiRNAs were profiled by TaqMan MicroRNA Array and(More)
The electric potential of the contractile vacuole (CV) of Paramecium multimicronucleatum was measured in situ using microelectrodes, one placed in the CV and the other (reference electrode) in the cytosol of a living cell. The CV potential in a mechanically compressed cell increased in a stepwise manner to a maximal value (approximately 80 mV) early in the(More)
The rate of fluid expulsion, R(CVC), from the contractile vacuole complex (CVC) of Paramecium multimicronucleatum was estimated from the volume of the contractile vacuoles (CVs) immediately before the start of fluid discharge and from the time elapsing between discharges. The R(CVC) increased when the cell was exposed to a strongly hypotonic solution and(More)
To develop spatially continuous seismicity models (earthquake probability distributions) from a given earthquake catalog, the method of kernel estimation has been suggested. Kernel estimations with a global (spatially invariant) bandwidth deal poorly with earthquake hypocenter distributions that have different spatially local features. For example, a(More)
Their glycolytic metabolism imposes an increased acid load upon tumour cells. The surplus protons are extruded by the Na+/H+ exchanger (NHE) which causes an extracellular acidification. It is not yet known by what mechanism extracellular pH (pHe) and NHE activity affect tumour cell migration and thus metastasis. We studied the impact of pHe and NHE activity(More)
OBJECTIVE To study the time dependent effectiveness of thrombolytic therapy for acute ischaemic stroke in daily clinical practice. DESIGN A retrospective cohort study using data from a large scale, comprehensive population based state-wide stroke registry in Germany. SETTING All 148 hospitals involved in acute stroke care in a large state in southwest(More)
Oncogenic transformation involves reprogramming of cell metabolism, whereby steady-state levels of intracellular NAD+ and NADH can undergo dramatic changes while ATP concentration is generally well maintained. Altered expression of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of NAD+-salvage, accompanies the changes in NAD(H)(More)
Computer-assisted minimally-invasive surgery (MIS) is often based on algorithms that require establishing correspondences between endoscopic images. However, reference annotations frequently required to train or validate a method are extremely difficult to obtain because they are typically made by a medical expert with very limited resources, and publicly(More)