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Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29Expand
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Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative andExpand
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A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan
Marine seaweeds increasingly grow into extensive algal blooms, which are detrimental to coastal ecosystems, tourism and aquaculture. However, algal biomass is also emerging as a sustainable rawExpand
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Biochemical characterization of an ulvan lyase from the marine flavobacterium Formosa agariphila KMM 3901T
Carbohydrates are the product of carbon dioxide fixation by algae in the ocean. Their polysaccharides are depolymerized by marine bacteria, with a vast array of carbohydrate-active enzymes. TheseExpand
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Liposome fusion on proteinaceous S-layer lattices triggered viaβ-diketone ligand–europium(III) complex formation
The present study describes a method for generating solid supported lipid membranes. Liposomes containing β-diketone ligands were chemically bound to crystalline surface (S-) layer proteins whichExpand
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Complexation of metals by phytosiderophores revealed by CE‐ESI‐MS and CE‐ICP‐MS
CE‐ESI‐MS and CE‐ICP‐MS were implemented for studying three phytosiderophores (mugineic acid, epi‐mugineic acid and deoxymugineic acid) and their metal complexes. Free ligands and ferric complexesExpand
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Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition ofExpand
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Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide.
Bacteria from the Burkholderia cepacia complex (Bcc) cause highly contagious pneumonia among cystic fibrosis (CF) patients. Among them, Burkholderia cenocepacia is one of the most dangerous in theExpand
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Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition ofExpand
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Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent
This study describes the synthesis of a fluoroethylated derivative of [N-methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an alreadyExpand
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