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- Publications
- Influence
Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
- Igor Beseda, Laszlo Czollner, +11 authors U. Jordis
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 2010
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29… Expand
Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
- Nicholas Holmes, Geoffrey R Akien, +9 authors Richard A Bourne
- Chemistry
- 3 February 2016
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and… Expand
A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan
- Lukas Reisky, Aurélie Préchoux, +16 authors Jan-Hendrik Hehemann
- Chemistry, Medicine
- Nature Chemical Biology
- 8 July 2019
Marine seaweeds increasingly grow into extensive algal blooms, which are detrimental to coastal ecosystems, tourism and aquaculture. However, algal biomass is also emerging as a sustainable raw… Expand
Biochemical characterization of an ulvan lyase from the marine flavobacterium Formosa agariphila KMM 3901T
- Lukas Reisky, Christian Stanetty, M. Mihovilovic, T. Schweder, Jan-Hendrik Hehemann, U. Bornscheuer
- Chemistry, Medicine
- Applied Microbiology and Biotechnology
- 12 June 2018
Carbohydrates are the product of carbon dioxide fixation by algae in the ocean. Their polysaccharides are depolymerized by marine bacteria, with a vast array of carbohydrate-active enzymes. These… Expand
Liposome fusion on proteinaceous S-layer lattices triggered viaβ-diketone ligand–europium(III) complex formation
- A. Schrems, Vanessa D. Larisch, +4 authors B. Schuster
- Chemistry
- 7 June 2011
The present study describes a method for generating solid supported lipid membranes. Liposomes containing β-diketone ligands were chemically bound to crystalline surface (S-) layer proteins which… Expand
Complexation of metals by phytosiderophores revealed by CE‐ESI‐MS and CE‐ICP‐MS
- Madeleine Dell'mour, G. Koellensperger, +5 authors S. Hann
- Chemistry, Medicine
- Electrophoresis
- 1 April 2010
CE‐ESI‐MS and CE‐ICP‐MS were implemented for studying three phytosiderophores (mugineic acid, epi‐mugineic acid and deoxymugineic acid) and their metal complexes. Free ligands and ferric complexes… Expand
Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
- Christian Stanetty, Laszlo Czollner, +7 authors Dirk Classen-Houben
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 November 2010
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of… Expand
Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide.
- Roberta Marchetti, L. Malinovska, +9 authors A. Silipo
- Biology, Medicine
- Glycobiology
- 1 October 2012
Bacteria from the Burkholderia cepacia complex (Bcc) cause highly contagious pneumonia among cystic fibrosis (CF) patients. Among them, Burkholderia cenocepacia is one of the most dangerous in the… Expand
Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
- Rawindra Gaware, R. Khunt, +7 authors Dirk Classen-Houben
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 March 2011
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of… Expand
Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent
- U. E. C. Berndt, Christian Stanetty, +9 authors C. Noe
- Chemistry
- 15 March 2008
This study describes the synthesis of a fluoroethylated derivative of [N-methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an already… Expand