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When the drug trial fails: an approach to clinical drug studies.

• Mikhal Gold, Signe A Todd, Christian Spiegler, Jeffrey Allen Gold
• AANA journal
• 1999

Drug development involves the chemical identification and characterization of a compound to determine stability and define the drug's preliminary actions. Preclinical research follows in animals to… (More)

[Tear production in premature infants, newborn infants and infants].

• Christian Spiegler, Uwe Mayer
• Klinische Monatsblatter fur Augenheilkunde
• 1993

These investigations concerned 50 babies at the age of 34 to 47 weeks and two days. After local instillation of anesthetic drops, Schirmer-1-test was done. The average basal tear production was 5 mm… (More)

Estrogen receptor beta gene (ESRbeta) 3'-UTR variants in Alzheimer disease.

• Christian Luckhaus, Christian Spiegler, +11 authors Philipp G Sand
• Alzheimer disease and associated disorders
• 2006

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