Christian Schenk

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In asymmetrically dividing cells, a failure to coordinate cell polarity with the site of cell division can lead to cell fate transformations and tumorigenesis. Cell polarity in C. elegans embryos is defined by PAR proteins, which occupy reciprocal halves of the cell cortex. During asymmetric division, the boundary between the anterior and posterior PAR(More)
BACKGROUND The foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for protease dimerization and activation. The D element functions as internal polypurine tract during reverse transcription. Peters et al.,(More)
Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk(More)
Realistic and efficient reliability estimation for aerospace structures. Abstract In this paper an efficient procedure for calculating non-exceedance probabilities of the structural response is presented, with emphasis on structures modeled by large finite element systems with many uncertain parameters. This is a problem which receives considerable(More)
In this paper an efficient procedure for calculating non-exceedance probabilities of large finite element systems with a large number of uncertain parameters is presented, a problem which receives considerably attention in space engineering. For this purpose, a novel sampling procedure is introduced, which allows a significant reduction of the variance of(More)
of large, non-linear finite element systems under stochastic loading. Abstract A very efficient and straightforward numerical procedure for the computation of statistical second moment characteristics of large, non-linear finite element systems under stochastic loading is presented. For the modeling of both the loading and the response of the system an(More)