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The reconstruction of destroyed paper documents became of more interest during the last years. On the one hand it (often) occurs that documents are destroyed by mistake while on the other hand this type of application is relevant in the fields of forensics and archeology, e.g., for evidence or restoring ancient documents. Within this paper, we present a new(More)
GnRH signaling regulates reproductive physiology in vertebrates via the hypothalamic-pituitary-gonadal axis. In addition, GnRH signaling has been postulated to act on the brain. However, elucidating its functional role in the central nervous system has been hampered because of the difficulty in identifying direct GnRH signaling targets in live brain tissue.(More)
This master thesis focuses on the reconstruction of destroyed text documents, which were mechanically destructed with the help of so-called cross-cut shredders. These machines cut a piece of paper into equally sized, usually rectangular, slices, which leads to the fact that these shreds are indistinguishable on the basis of their shape. The ambition of this(More)
In Austria, 700 women are diagnosed every year with ovarian carcinoma. Approximately 15% of the patients with epithelial ovarian cancer have a germline mutation in the BRCA1 or BRCA2 genes. The increased incidence of breast and/or ovarian cancer in genetically related family members has given rise to the term "hereditary breast and ovarian cancer syndrome"(More)
Despite an enormous increase in our knowledge about the mechanisms underlying the encoding of information in the brain, a central question concerning the precise molecular steps as well as the activity of specific neurons in multi-functional nuclei of brain areas such as the hypothalamus remain. This problem includes identification of the molecular(More)
We introduce the Three-Layer Hierarchical Ring Network Design Problem, which arises especially in the design of large telecom-munication networks. The aim is to connect nodes that are assigned to three different layers using rings of bounded length. We present tailored Variable Neighborhood Search (VNS) and GRASP approaches to solve large instances of this(More)