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Histone H3 lysine 9 methylation has been proposed to provide a major "switch" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone methyltransferases (HMTases) govern H3-K9 methylation at pericentric heterochromatin and induce a specialized histone methylation pattern that differs from the broad H3-K9(More)
We investigate synchronization between cardiovascular and respiratory systems in healthy humans under free-running conditions. For this aim we analyze nonstationary irregular bivariate data, namely, electrocardiograms and measurements of respiratory flow. We briefly discuss a statistical approach to synchronization in noisy and chaotic systems and(More)
A Monte Carlo algorithm is said to be adaptive if it automatically calibrates its current proposal distribution using past simulations. The choice of the parametric family that defines the set of proposal distributions is critical for good performance. In this paper, we present such a parametric family for adaptive sampling on high-dimensional binary(More)
c-erbB receptors are usually located in cell membranes and are activated by extracellular binding of EGF-like growth factors. Unexpectedly, using immunofluorescence we found high levels of c-erbB-3 within the nuclei of MTSV1-7 immortalized nonmalignant human mammary epithelial cells. Nuclear localization was mediated by the COOH terminus of c-erbB-3, and a(More)
We discuss a unified approach to stochastic optimization of pseudo-Boolean objective functions based on particle methods, including the cross-entropy method and simulated annealing as special cases. We point out the need for auxiliary sampling distributions, meaning parametric families on binary spaces, which are able to reproduce complex dependency(More)
The design of suitable packet-filters protecting subnets against network based attacks is usually difficult and error-prone. Therefore, tool-assistance shall facilitate the design task and shall contribute to the correctness of the filters, i.e., the filters should be consistent with the other security mechanisms of the computer network, in particular with(More)
The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure and gene expression, thereby controlling important developmental processes. In the mouse brain, HDAC1 and HDAC2 exhibit different developmental stage- and lineage-specific expression patterns. To examine the individual contribution of these deacetylases during brain(More)
This document is the aggregation of several discussions of Lopes et al. (2010) we submitted to conjunction with Hedibert Lopes' talk at this meeting. The main point in those discussions is the potential for degeneracy in the particle learning methodology, related with the exponential forgetting of the past simulations. We illustrate the resulting(More)