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Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
For a successful analysis of the relation between amino acid sequence and protein structure, an unambiguous and physically meaningful definition of secondary structure is essential. We have developed… Expand
Protein structure comparison by alignment of distance matrices.
With a rapidly growing pool of known tertiary structures, the importance of protein structure comparison parallels that of sequence alignment. We have developed a novel algorithm (DALI) for optimal… Expand
Prediction of protein secondary structure at better than 70% accuracy.
We have trained a two-layered feed-forward neural network on a non-redundant data base of 130 protein chains to predict the secondary structure of water-soluble proteins. A new key aspect is the use… Expand
Dali: a network tool for protein structure comparison.
Mapping the Protein Universe
The comparison of the three-dimensional shapes of protein molecules poses a complex algorithmic problem. Its solution provides biologists with computational tools to organize the rapidly growing set… Expand
Database of homology-derived protein structures and the structural meaning of sequence alignment.
The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences,… Expand
Combining evolutionary information and neural networks to predict protein secondary structure.
Using evolutionary information contained in multiple sequence alignments as input to neural networks, secondary structure can be predicted at significantly increased accuracy. Here, we extend our… Expand
Enlarged representative set of protein structures.
- U. Hobohm, Christian Sander
- Medicine, Biology
- Protein science : a publication of the Protein…
- 31 December 2008
To reduce redundancy in the Protein Data Bank of 3D protein structures, which is caused by many homologous proteins in the data bank, we have selected a representative set of structures. The… Expand
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
- P. Bork, Christian Sander, A. Valéncia
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 August 1992
The functionally diverse actin, hexokinase, and hsp70 protein families have in common an ATPase domain of known three-dimensional structure. Optimal superposition of the three structures and… Expand
Conservation and prediction of solvent accessibility in protein families.
Currently, the prediction of three-dimensional (3D) protein structure from sequence alone is an exceedingly difficult task. As an intermediate step, a much simpler task has been pursued extensively:… Expand