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Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
For a successful analysis of the relation between amino acid sequence and protein structure, an unambiguous and physically meaningful definition of secondary structure is essential. We have developedExpand
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Protein structure comparison by alignment of distance matrices.
With a rapidly growing pool of known tertiary structures, the importance of protein structure comparison parallels that of sequence alignment. We have developed a novel algorithm (DALI) for optimalExpand
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Prediction of protein secondary structure at better than 70% accuracy.
We have trained a two-layered feed-forward neural network on a non-redundant data base of 130 protein chains to predict the secondary structure of water-soluble proteins. A new key aspect is the useExpand
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Dali: a network tool for protein structure comparison.
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Mapping the Protein Universe
The comparison of the three-dimensional shapes of protein molecules poses a complex algorithmic problem. Its solution provides biologists with computational tools to organize the rapidly growing setExpand
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Database of homology-derived protein structures and the structural meaning of sequence alignment.
The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences,Expand
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Combining evolutionary information and neural networks to predict protein secondary structure.
Using evolutionary information contained in multiple sequence alignments as input to neural networks, secondary structure can be predicted at significantly increased accuracy. Here, we extend ourExpand
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Enlarged representative set of protein structures.
To reduce redundancy in the Protein Data Bank of 3D protein structures, which is caused by many homologous proteins in the data bank, we have selected a representative set of structures. TheExpand
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An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
The functionally diverse actin, hexokinase, and hsp70 protein families have in common an ATPase domain of known three-dimensional structure. Optimal superposition of the three structures andExpand
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Conservation and prediction of solvent accessibility in protein families.
Currently, the prediction of three-dimensional (3D) protein structure from sequence alone is an exceedingly difficult task. As an intermediate step, a much simpler task has been pursued extensively:Expand
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