Christian Sander

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.

For a successful analysis of the relation between amino acid sequence and protein structure, an unambiguous and physically meaningful definition of secondary structure is essential. We have developed… (More)

Protein structure comparison by alignment of distance matrices.

Liisa Holm, Christian Sander
Journal of molecular biology
1993

With a rapidly growing pool of known tertiary structures, the importance of protein structure comparison parallels that of sequence alignment. We have developed a novel algorithm (DALI) for optimal… (More)

Prediction of protein secondary structure at better than 70% accuracy.

Burkhard Rost, Christian Sander
Journal of molecular biology
1993

We have trained a two-layered feed-forward neural network on a non-redundant data base of 130 protein chains to predict the secondary structure of water-soluble proteins. A new key aspect is the use… (More)

Mapping the protein universe.

The comparison of the three-dimensional shapes of protein molecules poses a complex algorithmic problem. Its solution provides biologists with computational tools to organize the rapidly growing set… (More)

Dali: a network tool for protein structure comparison.

Liisa Holm, Christian Sander
Trends in biochemical sciences
1995

Database of homology-derived protein structures and the structural meaning of sequence alignment.

The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences,… (More)

Combining evolutionary information and neural networks to predict protein secondary structure.

Using evolutionary information contained in multiple sequence alignments as input to neural networks, secondary structure can be predicted at significantly increased accuracy. Here, we extend our… (More)

Enlarged representative set of protein structures.

Uwe Hobohm, Christian Sander
Protein science : a publication of the Protein…
1994

To reduce redundancy in the Protein Data Bank of 3D protein structures, which is caused by many homologous proteins in the data bank, we have selected a representative set of structures. The… (More)

Redefining the goals of protein secondary structure prediction.

Burkhard Rost, Christian Sander, Robert Schneider
Journal of molecular biology
1994

Secondary structure prediction recently has surpassed the 70% level of average accuracy, evaluated on the single residue states helix, strand and loop (Q3). But the ultimate goal is reliable… (More)

Conservation and prediction of solvent accessibility in protein families.

Currently, the prediction of three-dimensional (3D) protein structure from sequence alone is an exceedingly difficult task. As an intermediate step, a much simpler task has been pursued extensively:… (More)

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