Christian Riml

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Acidic proteins and nucleic acids such as RNA are most readily ionized in electrospray ionization (ESI) operated in negative-ion mode. The multiply deprotonated protein or RNA ions can be used as precursors in top- down mass spectrometry. Because the performance of the dissociation method used critically depends on precursor ion negative net charge, it is(More)
Ribonucleic acid (RNA) modifications play an important role in the regulation of gene expression and the development of RNA-based therapeutics, but their identification, localization and relative quantitation by conventional biochemical methods can be quite challenging. As a promising alternative, mass spectrometry (MS) based approaches that involve RNA(More)
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